| DXP00001 | USP1 | A Proteomic Approach for Systematic Mapping of Substrates of HumanDeubiquitinating Enzymes. | Proteomics (Label-free) | HEK293 | Homo sapiens | 2021-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00002 | USP7 | A Proteomic Approach for Systematic Mapping of Substrates of HumanDeubiquitinating Enzymes. | Proteomics (Label-free) | HEK293 | Homo sapiens | 2021-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00003 | USP9X | A Proteomic Approach for Systematic Mapping of Substrates of HumanDeubiquitinating Enzymes. | Proteomics (Label-free) | HEK293 | Homo sapiens | 2021-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00004 | USP11 | A Proteomic Approach for Systematic Mapping of Substrates of HumanDeubiquitinating Enzymes. | Proteomics (Label-free) | HEK293 | Homo sapiens | 2021-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00005 | USP42 | A Proteomic Approach for Systematic Mapping of Substrates of HumanDeubiquitinating Enzymes. | Proteomics (Label-free) | HEK293 | Homo sapiens | 2021-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00006 | USP30 | Dynamic Regulation of Mitochondrial Import by the Ubiquitin System. | Proteomics (TMT) | HEK293 | Homo sapiens | 2020-03-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00007 | USP7 | Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale. | Manual (MS-based) | HTC116 | Homo sapiens | 2021-09-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00008 | USP14 | Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosisvia stabilization of FASN. | Manual (MS-based) | HeLa | Homo sapiens | 2018-11-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00009 | USP14 | Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinatedproteins in mammalian cells. | Manual (MS-based) | HEK293 | Homo sapiens | 2019-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00010 | UCHL5 | Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinatedproteins in mammalian cells. | Manual (MS-based) | HEK293 | Homo sapiens | 2019-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00011 | TNFAIP3 | ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. | Manual (Western-based) | HEK293 | Homo sapiens | 2006-05-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00012 | OTUD5 | Effect of Deubiquitinase Ovarian Tumor Domain-Containing Protein 5 (OTUD5) onRadiosensitivity of Cervical Cancer by Regulating the Ubiquitination of Akt andits Mechanism. | Manual (Western-based) | C33A | Homo sapiens | 2019-05-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00013 | ATXN3 | The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkinubiquitination and stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-10-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00014 | OTUD1 | DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00015 | OTUD7B | OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migrationvia deubiquitinating TRAF3. | Manual (Western-based) | H1299 | Homo sapiens | 2020-11-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00016 | OTUD1 | SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAPnuclear localization and activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-06-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00017 | YOD1 | YOD1 Deubiquitinates NEDD4 Involved in the Hippo Signaling Pathway. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00018 | OTUD7B | Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B bysponging miR-137 involving EGFR/MAPK pathway. | Manual (Western-based) | MIA PACA2 | Homo sapiens | 2019-11-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00019 | OTUB1 | Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibitsinflammation by regulating Nur77 stability. | Manual (Western-based) | HeLa | Homo sapiens | 2019-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00020 | OTUD7B | Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neuralprogenitor cell differentiation. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-11-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00021 | OTUD4 | Induction of OTUD4 by viral infection promotes antiviral responses throughdeubiquitinating and stabilizing MAVS. | Manual (Western-based) | HEK293 | Homo sapiens | 2018-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00022 | ZRANB1 | Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. | Manual (Western-based) | Huh7 | Homo sapiens | 2019-01-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00023 | OTUB1 | Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression viapreventing ER-associated degradation of immune checkpoint protein PD-L1. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-12-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00024 | TNFAIP3 | A20-mediated deubiquitination of ERalpha in the microenvironment of CD163(+)macrophages sensitizes endometrial cancer cells to estrogen. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-10-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00025 | JOSD1 | JOSD1 inhibits mitochondrial apoptotic signalling to drive acquiredchemoresistance in gynaecological cancer by stabilizing MCL1. | Manual (Western-based) | A2780 | Homo sapiens | 2019-05-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00026 | YOD1 | YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-02-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00027 | ATXN3 | The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2. | Manual (Western-based) | 8505c | Homo sapiens | 2021-08-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00028 | YOD1 | YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB. | Manual (Western-based) | HeLa | Homo sapiens | 2017-02-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00029 | OTUB2 | OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-11-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00030 | OTUD3 | The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis. | Manual (Western-based) | H1299 | Homo sapiens | 2019-07-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00031 | ZRANB1 | Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linkedpolyubiquitin is recruited by SQSTM1/p62. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-01-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00032 | OTUD3 | Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in InnateAntiviral Immunity. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00033 | OTUB1 | OTUB1 modulates c-IAP1 stability to regulate signalling pathways. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-03-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00034 | TNFAIP3 | The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3and protects cells from necroptosis. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-05-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00035 | OTUD5 | OTUD5 regulates p53 stability by deubiquitinating p53. | Manual (Western-based) | H1299 | Homo sapiens | 2013-10-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00036 | OTUD1 | Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53. | Manual (Western-based) | U2OS | Homo sapiens | 2017-02-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00037 | YOD1 | The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling AdaptorMAVS through Lys63-Linked Deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-04-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00038 | TNFAIP3 | The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. | Manual (Western-based) | HEK293 | Homo sapiens | 2010-04-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00039 | YOD1 | Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCHstability. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-04-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00040 | JOSD1 | JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity byDeubiquitinating and Stabilizing SOCS1. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-03-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00041 | ZRANB1 | Epigenetic regulation of the expression of Il12 and Il23 and autoimmuneinflammation by the deubiquitinase Trabid. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-01-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00042 | OTUD5 | The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining. | Manual (Western-based) | H1299 | Homo sapiens | 2019-04-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00043 | OTUB1 | Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. | Manual (Western-based) | U2OS | Homo sapiens | 2011-11-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00044 | OTUD3 | Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directlydeubiquitinating and stabilizing p53 in invasive breast carcinoma cells. | Manual (Western-based) | MCF7 | Homo sapiens | 2020-06-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00045 | OTUD4 | Noncanonical regulation of alkylation damage resistance by the OTUD4deubiquitinase. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-05-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00046 | ATXN3 | Polyglutamine tracts regulate beclin 1-dependent autophagy. | Manual (Western-based) | HeLa | Homo sapiens | 2017-04-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00047 | OTUD7B | TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2signalling. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-05-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00048 | ATXN3 | The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2. | Manual (Western-based) | SW1736 | Homo sapiens | 2021-08-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00049 | ATXN3 | TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-06-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00050 | OTUB2 | Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cellactivation in bile duct ligation rats by promoting YAP degradation. | Manual (Western-based) | LX-2 | Homo sapiens | 2021-08-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00051 | JOSD2 | The deubiquitinase JOSD2 is a positive regulator of glucose metabolism. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00052 | ZRANB1 | ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in BreastCancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00053 | OTUB1 | OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulatingSnail stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00054 | JOSD2 | The deubiquitinase JOSD2 is a positive regulator of glucose metabolism. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00055 | OTUD4 | Noncanonical regulation of alkylation damage resistance by the OTUD4deubiquitinase. | Manual (Western-based) | PC3 | Homo sapiens | 2015-05-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00056 | OTUD1 | Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-12-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00057 | OTUD5 | Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 inresponse to genotoxic stress. | Manual (Western-based) | HCT116 | Homo sapiens | 2014-12-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00058 | OTUB1 | OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression andpredicts a poor prognosis in ovarian cancer. | Manual (Western-based) | SKOV3 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00059 | OTUB2 | OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via theAKT/mTOR signaling pathway in non-small cell lung cancer. | Manual (Western-based) | H1299 | Homo sapiens | 2019-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00060 | OTUD4 | OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-DependentSignaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00061 | OTUB2 | Regulation of Gli2 stability by deubiquitinase OTUB2. | Manual (Western-based) | HEK293A | Homo sapiens | 2018-09-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00062 | OTUB2 | OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via theAKT/mTOR signaling pathway in non-small cell lung cancer. | Manual (Western-based) | XL-2 | Homo sapiens | 2019-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00063 | TNFAIP3 | TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. | Manual (Western-based) | HCT116 | Homo sapiens | 2011-10-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00064 | TNFAIP3 | A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1ubiquitin chains. | Manual (Western-based) | Jurkat T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00065 | OTUD1 | The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-08-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00066 | OTUD1 | OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-03-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00067 | TNFAIP3 | Functional analysis of novel A20 variants in patients with atypical inflammatory diseases. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00068 | OTUB1 | OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating themTORC1 inhibitor DEPTOR. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-01-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00069 | ATXN3 | ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00070 | OTUB2 | OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-11-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00071 | OTUB1 | Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. | Manual (Western-based) | H1299 | Homo sapiens | 2011-11-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00072 | OTUD1 | Induction of OTUD1 by RNA viruses potently inhibits innate immune responses bypromoting degradation of the MAVS/TRAF3/TRAF6 signalosome. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00073 | OTUB1 | OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression andpredicts a poor prognosis in ovarian cancer. | Manual (Western-based) | CAOV3 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00074 | OTUD1 | OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00075 | TNFAIP3 | A De Novo Frameshift Mutation in TNFAIP3 Impairs A20 Deubiquitination Function toCause Neuropsychiatric Systemic Lupus Erythematosus. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-10-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00076 | OTUD5 | OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity. | Manual (Western-based) | HEP3B | Homo sapiens | 2020-08-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00077 | OTUB2 | Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNArepair pathway choice. | Manual (Western-based) | U2OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00078 | OTUD5 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinatingand stabilizing STING. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-09-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00079 | OTUB2 | Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediateddeubiquitination of TRAF3 and TRAF6. | Manual (Western-based) | HEK293 | Homo sapiens | 2009-12-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00080 | OTUD7A | Snail1-dependent transcriptional repression of Cezanne2 in hepatocellularcarcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-06-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00081 | TNFAIP3 | De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaBsignalling. | Manual (Western-based) | HEK293T | Homo sapiens | 2004-07-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00082 | ZRANB1 | Trabid inhibits hepatocellular carcinoma growth and metastasis by cleavingRNF8-induced K63 ubiquitination of Twist1. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00083 | OTUD7B | OTUD7B controls non-canonical NF-kappaB activation through deubiquitination ofTRAF3. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-01-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00084 | OTUD6A | OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00085 | OTUB1 | Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression viapreventing ER-associated degradation of immune checkpoint protein PD-L1. | Manual (Western-based) | MDA-MB-231 | Homo sapiens | 2020-12-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00086 | TNFAIP3 | TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-03-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00087 | OTUD1 | OTUD1 Negatively Regulates Type I IFN Induction by Disrupting NoncanonicalUbiquitination of IRF3. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-02-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00088 | OTUD5 | Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signalingpathways. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00089 | OTUD1 | Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-08-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00090 | OTUD1 | OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00091 | OTUD3 | Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directlydeubiquitinating and stabilizing p53 in invasive breast carcinoma cells. | Manual (Western-based) | DU4475 | Homo sapiens | 2020-06-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00092 | JOSD1 | JOSD1 inhibits mitochondrial apoptotic signalling to drive acquiredchemoresistance in gynaecological cancer by stabilizing MCL1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-05-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00093 | ZRANB1 | Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-01-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00094 | ATXN3 | ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00095 | OTUB1 | The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00096 | OTUD7B | Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B bysponging miR-137 involving EGFR/MAPK pathway. | Manual (Western-based) | PANC-1 | Homo sapiens | 2019-11-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00097 | OTUD5 | OTUD5-mediated deubiquitination of YAP in macrophage promotes M2 phenotypepolarization and favors triple-negative breast cancer progression. | Manual (Western-based) | THP-1-derived macrophages | Homo sapiens | 2021-02-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00098 | OTUB1 | Scavenger receptor A impairs interferon response to HBV infection by limitingTRAF3 ubiquitination through recruiting OTUB1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-08-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00099 | OTUD5 | DUBA: a deubiquitinase that regulates type I interferon production. | Manual (Western-based) | HEK293 | Homo sapiens | 2007-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00100 | OTUD6A | Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. | Manual (Western-based) | HEK293 | Homo sapiens | 2020-11-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00101 | OTUD7B | High-throughput screening of functional deubiquitinating enzymes in autophagy. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00102 | JOSD2 | The deubiquitinase JOSD2 is a positive regulator of glucose metabolism. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00103 | ATXN3L | Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinatingenzymes, promotes breast cancer proliferation by deubiquitinating Kruppel-likefactor 5 (KLF5). | Manual (Western-based) | HEK293FT | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00104 | BAP1 | BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing celltransformation. | Manual (Western-based) | HEK-293 | Homo sapiens | 2017-06-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00105 | BAP1 | Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cellcarcinoma. | Manual (Western-based) | 786-O | Homo sapiens | 2015-08-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00106 | BAP1 | BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinatingKLF5. | Manual (Western-based) | HEK293FT | Homo sapiens | 2015-09-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00107 | BAP1 | Deubiquitination of gamma-tubulin by BAP1 prevents chromosome instability inbreast cancer cells. | Manual (Western-based) | MDA-MB-468 | Homo sapiens | 2014-09-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00108 | BAP1 | O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis bymodulating PGC-1alpha stability. | Manual (Western-based) | HEK 293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00109 | BAP1 | BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizingPTEN. | Manual (Western-based) | 293T | Homo sapiens | 2020-11-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00110 | BAP1 | BAP1 regulates AMPK-mTOR signalling pathway through deubiquitinating andstabilizing tumour-suppressor LKB1. | Manual (Western-based) | 293T cell | Homo sapiens | 2020-07-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00111 | BAP1 | BAP1 regulation of the key adaptor protein NCoR1 is critical for gamma-globingene repression. | Manual (Western-based) | 293T | Homo sapiens | 2018-11-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00112 | BAP1 | BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinatingKLF5. | Manual (Western-based) | HCC1806 | Homo sapiens | 2015-09-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00113 | BAP1 | BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma. | Manual (Western-based) | 786-O | Homo sapiens | 2020-05-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00114 | BAP1 | Stabilization and targeting of INO80 to replication forks by BAP1 during normalDNA synthesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-10-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00115 | BAP1 | The deubiquitinating enzyme BAP1 regulates cell growth via interaction withHCF-1. | Manual (Western-based) | 293T | Homo sapiens | 2009-10-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00116 | BRCC3 | Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-MediatedDeubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00117 | BRCC3 | Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00118 | BRCC3 | Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36controls the timing of sister telomere resolution. | Manual (Western-based) | HTC75 | Homo sapiens | 2016-12-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00119 | BRCC3 | The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffoldproteins localizing in different subcellular compartments. | Manual (Western-based) | HeLa | Homo sapiens | 2010-07-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00120 | BRCC3 | Functional characterization of BRCC3 mutations in acute myeloid leukemia witht(8;21)(q22;q22.1). | Manual (Western-based) | HEK293T | Homo sapiens | 2019-10-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00121 | BRCC3 | The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00122 | COPS5 | PDIA6 promotes pancreatic cancer progression and immune escape throughCSN5-mediated deubiquitination of beta-catenin and PD-L1. | Manual (Western-based) | BxPC3 | Homo sapiens | 2021-07-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00123 | COPS5 | CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilizationof FOXM1. | Manual (Western-based) | PANC1 | Homo sapiens | 2018-10-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00124 | COPS5 | CSN5 upregulates glycolysis to promote hepatocellular carcinoma metastasis viastabilizing the HK2 protein. | Manual (Western-based) | HCCLM3 | Homo sapiens | 2020-01-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00125 | COPS5 | CSN5 attenuates Ang II-induced cardiac hypertrophy through stabilizing LKB1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-01-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00126 | COPS5 | Roles for CSN5 in control of p53/MDM2 activities. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00127 | COPS5 | LncRNA GATA3-AS1 facilitates tumour progression and immune escape intriple-negative breast cancer through destabilization of GATA3 but stabilization of PD-L1. | Manual (Western-based) | TNBC | Homo sapiens | 2020-07-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00128 | COPS5 | CSN5 controls the growth of osteosarcoma via modulating the EGFR/PI3K/Akt axis. | Manual (Western-based) | U2OS | Homo sapiens | 2019-09-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00129 | COPS5 | CSN5 promotes renal cell carcinoma metastasis and EMT by inhibiting ZEB1degradation. | Manual (Western-based) | ACHN | Homo sapiens | 2017-05-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00130 | COPS5 | COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein(VCP) and controls the ubiquitination status of proteins bound to p97/VCP. | Manual (Western-based) | HEK293T | Homo sapiens | 2009-10-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00131 | COPS5 | CSN5/Jab1 facilitates non-small cell lung cancer cell growth through stabilizing survivin. | Manual (Western-based) | H460 | Homo sapiens | 2018-04-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00132 | COPS5 | CSN5 Promotes Hepatocellular Carcinoma Progression by SCARA5 Inhibition ThroughSuppressing beta-Catenin Ubiquitination. | Manual (Western-based) | MHCC97H | Homo sapiens | 2017-11-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00133 | COPS5 | Berberine diminishes cancer cell PD-L1 expression and facilitates antitumorimmunity via inhibiting the deubiquitination activity of CSN5. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-06-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00134 | COPS5 | Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00135 | COPS5 | Deubiquitination and Stabilization of PD-L1 by CSN5. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00136 | COPS5 | PEA15 regulates the DNA damage-induced cell cycle checkpoint andoncogene-directed transformation. | Manual (Western-based) | HCT116 | Homo sapiens | 2014-04-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00137 | COPS6 | ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal CancerDevelopment. | Manual (Western-based) | DLD-1 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00138 | COPS6 | CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediateddegradation of EGFR. | Manual (Western-based) | U-87-MG | Homo sapiens | 2016-08-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00139 | COPS6 | CSN6 drives carcinogenesis by positively regulating Myc stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-11-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00140 | COPS6 | CSN6 promotes the cell migration of breast cancer cells by positively regulating Snail1 stability. | Manual (Western-based) | MDA-MB-231 | Homo sapiens | 2020-10-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00141 | COPS6 | COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer. | Manual (Western-based) | HeLa | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00142 | COPS6 | CSN6 positively regulates c-Jun in a MEKK1-dependent manner. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-08-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00143 | COPS6 | Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice throughstabilization of MDM2 and is upregulated in human cancers. | Manual (Western-based) | H1299 | Homo sapiens | 2011-02-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00144 | COPS6 | CSN6 promotes the cell migration of breast cancer cells by positively regulating Snail1 stability. | Manual (Western-based) | BT549 | Homo sapiens | 2020-10-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00145 | COPS6 | CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediateddegradation of EGFR. | Manual (Western-based) | LN-229 | Homo sapiens | 2016-08-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00146 | COPS6 | CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizingthe c-Fos protein. | Manual (Western-based) | CFPAC-1 | Homo sapiens | 2020-04-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00147 | COPS6 | CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-03-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00148 | COPS6 | CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by InhibitingAutophagic Degradation of Cathepsin L. | Manual (Western-based) | HeLa | Homo sapiens | 2019-05-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00149 | CYLD | The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signalingpathway. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-11-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00150 | CYLD | TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. | Manual (Western-based) | HEK293T | Homo sapiens | 2006-02-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00151 | CYLD | CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated alpha-Tubulin. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-06-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00152 | CYLD | Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-inducedinflammation by suppressing K63-linked ubiquitination of MyD88. | Manual (Western-based) | HeLa | Homo sapiens | 2015-12-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00153 | CYLD | Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progressionand viral replication. | Manual (Western-based) | HONE1-EBV | Homo sapiens | 2021-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00154 | CYLD | CYLD regulates spindle orientation by stabilizing astral microtubules andpromoting dishevelled-NuMA-dynein/dynactin complex formation. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-01-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00155 | CYLD | The deubiquitinase CYLD targets Smad7 protein to regulate transforming growthfactor beta (TGF-beta) signaling and the development of regulatory T cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-09-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00156 | CYLD | CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling atmultiple levels. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00157 | CYLD | Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB). | Manual (Western-based) | HEK293T | Homo sapiens | 2017-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00158 | CYLD | CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. | Manual (Western-based) | RPE-1 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00159 | CYLD | CYLD negatively regulates transforming growth factor-beta-signalling viadeubiquitinating Akt. | Manual (Western-based) | A549 | Homo sapiens | 2012-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00160 | CYLD | TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-09-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00161 | CYLD | The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator fortoll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. | Manual (Western-based) | HEK293T | Homo sapiens | 2005-10-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00162 | CYLD | Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinalinflammation. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00163 | CYLD | Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling throughK63-linked ubiquitination of Dvl. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00164 | CYLD | CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling atmultiple levels. | Manual (Western-based) | A431 | Homo sapiens | 2011-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00165 | CYLD | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 andinactivating HDAC6. | Manual (Western-based) | RPE-1 | Homo sapiens | 2014-10-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00166 | CYLD | Syndecan-4 negatively regulates antiviral signalling by mediating RIG-Ideubiquitination via CYLD. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-06-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00167 | CYLD | CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to RegulateInnate Immune Signaling. | Manual (Western-based) | U2-OS | Homo sapiens | 2016-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00168 | CYLD | Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cellleukemia/lymphoma (ATLL). | Manual (Western-based) | MT-4 | Homo sapiens | 2020-02-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00169 | CYLD | CYLD regulates RhoA activity by modulating LARG ubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-02-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00170 | CYLD | CYLD deubiquitinates RIP1 in the TNFalpha-induced necrosome to facilitate kinase activation and programmed necrosis. | Manual (Western-based) | HT29 | Homo sapiens | 2013-10-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00171 | CYLD | The tumour suppressor CYLD regulates the p53 DNA damage response. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00172 | CYLD | CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4Contributing to Adventitial Remodeling. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-07-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00173 | CYLD | The tumour suppressor CYLD regulates the p53 DNA damage response. | Manual (Western-based) | HCT116 | Homo sapiens | 2016-08-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00174 | CYLD | Regulation of T cell development by the deubiquitinating enzyme CYLD. | Manual (Western-based) | HEK293T | Homo sapiens | 2006-02-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00175 | CYLD | Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progressionand viral replication. | Manual (Western-based) | HK1-EBV | Homo sapiens | 2021-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00176 | CYLD | Cylindromatosis (CYLD) inhibits Streptococcus pneumonia-induced plasminogenactivator inhibitor-1 expression via interacting with TRAF-6. | Manual (Western-based) | A549 | Homo sapiens | 2015-06-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00177 | EIF3F | The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activityregulating Notch activation. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-11-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00178 | EIF3H | EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulatingSnail stability. | Manual (Western-based) | KYSE150 | Homo sapiens | 2020-08-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00179 | EIF3H | EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulatingSnail stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-08-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00180 | EIF3H | EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control ofYAP Stability. | Manual (Western-based) | MDA-MB-231 | Homo sapiens | 2020-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00181 | MINDY4 | FAM188B Expression Is Critical for Cell Growth via FOXM1 Regulation in LungCancer. | Manual (Western-based) | A549 | Homo sapiens | 2020-10-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00182 | MYSM1 | A histone H2A deubiquitinase complex coordinating histone acetylation and H1dissociation in transcriptional regulation. | Manual (Western-based) | HEK293 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00183 | OTULIN | Regulation of the linear ubiquitination of STAT1 controls antiviral interferonsignaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00184 | OTULIN | CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to RegulateInnate Immune Signaling. | Manual (Western-based) | THP1 | Homo sapiens | 2016-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00185 | OTULIN | Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00186 | OTULIN | Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00187 | OTULIN | LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. | Manual (Western-based) | A549 | Homo sapiens | 2015-12-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00188 | OTULIN | Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00189 | OTULIN | Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00190 | OTULIN | OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. | Manual (Western-based) | U2OS/NOD2 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00191 | OTULIN | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/beta-cateninactivation to enhance drug resistance in breast cancers. | Manual (Western-based) | MDA-MB-231 | Homo sapiens | 2020-08-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00192 | OTULIN | Molecular basis and regulation of OTULIN-LUBAC interaction. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00193 | OTULIN | The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhancedby its ability to degrade Otulin, which deubiquitinates IRF3. | Manual (Western-based) | HT1080 | Homo sapiens | 2021-09-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00194 | OTULIN | Cellular and Mathematical Analyses of LUBAC Involvement in T CellReceptor-Mediated NF-kappaB Activation Pathway. | Manual (Western-based) | Jurkat | Homo sapiens | 2020-11-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00195 | OTULIN | Cellular and Mathematical Analyses of LUBAC Involvement in T CellReceptor-Mediated NF-kappaB Activation Pathway. | Manual (Western-based) | Jurkat | Homo sapiens | 2020-11-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00196 | OTULIN | CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to RegulateInnate Immune Signaling. | Manual (Western-based) | U2OS/NOD2 | Homo sapiens | 2016-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00197 | OTULIN | OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linearpolyubiquitin. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-06-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00198 | OTULIN | CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to RegulateInnate Immune Signaling. | Manual (Western-based) | HCT116 | Homo sapiens | 2016-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00199 | OTULIN | OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. | Manual (Western-based) | U2OS/NOD2 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00200 | OTULIN | OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linkedpolyubiquitin. | Manual (Western-based) | T-Rex 293 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00201 | OTULIN | Global Screening of LUBAC and OTULIN Interacting Proteins by Human ProteomeMicroarray. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-06-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00202 | OTULIN | LUBAC and OTULIN regulate autophagy initiation and maturation by mediating thelinear ubiquitination and the stabilization of ATG13. | Manual (Western-based) | HEK293 | Homo sapiens | 2020-06-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00203 | OTULIN | CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to RegulateInnate Immune Signaling. | Manual (Western-based) | U2OS/NOD2 | Homo sapiens | 2016-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00204 | PRPF8 | Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor inProstate Cancer Cells. | Manual (Western-based) | C4-2 | Homo sapiens | 2015-09-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00205 | PRPF8 | Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor inProstate Cancer Cells. | Manual (Western-based) | LNCaP | Homo sapiens | 2015-09-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00206 | PSMD14 | The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistancethrough stabilizing the ALK2 receptor in the initiation of BMP6 signalingpathway. | Manual (Western-based) | HEK293FT | Homo sapiens | 2019-11-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00207 | PSMD14 | POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. | Manual (Western-based) | QGY7701 | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00208 | PSMD14 | Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness. | Manual (Western-based) | SCC-15 | Homo sapiens | 2021-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00209 | PSMD14 | POH1 contributes to hyperactivation of TGF-beta signaling and facilitateshepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptorsand caveolin-1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00210 | PSMD14 | POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. | Manual (Western-based) | QGY7701 | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00211 | PSMD14 | ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizingE2F1. | Manual (Western-based) | A172 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00212 | PSMD14 | POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. | Manual (Western-based) | SMMC-7721 | Homo sapiens | 2015-10-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00213 | PSMD14 | POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. | Manual (Western-based) | EC109 | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00214 | PSMD14 | Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-10-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00215 | PSMD14 | POH1 contributes to hyperactivation of TGF-beta signaling and facilitateshepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptorsand caveolin-1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00216 | PSMD14 | POH1 contributes to hyperactivation of TGF-beta signaling and facilitateshepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptorsand caveolin-1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00217 | PSMD14 | POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. | Manual (Western-based) | EC109 | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00218 | PSMD14 | Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness. | Manual (Western-based) | UM-1 | Homo sapiens | 2021-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00219 | PSMD14 | Selective autophagy controls the stability of transcription factor IRF3 tobalance type I interferon production and immune suppression. | Manual (Western-based) | A549 | Homo sapiens | 2020-05-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00220 | PSMD14 | ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizingE2F1. | Manual (Western-based) | LN229 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00221 | PSMD14 | Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2. | Manual (Western-based) | MHCC97 | Homo sapiens | 2019-10-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00222 | PSMD14 | POH1 deubiquitinates pro-interleukin-1beta and restricts inflammasome activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-10-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00223 | PSMD14 | ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizingE2F1. | Manual (Western-based) | U87 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00224 | PSMD14 | Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymaticactivity of PKM2. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-08-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00225 | PSMD14 | POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. | Manual (Western-based) | HTC116 | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00226 | PSMD14 | POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. | Manual (Western-based) | HTC116 | Homo sapiens | 2018-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00227 | PSMD14 | ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizingE2F1. | Manual (Western-based) | N3 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00228 | PSMD14 | The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistancethrough stabilizing the ALK2 receptor in the initiation of BMP6 signalingpathway. | Manual (Western-based) | HCT116 | Homo sapiens | 2019-11-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00229 | PSMD14 | POH1 contributes to hyperactivation of TGF-beta signaling and facilitateshepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptorsand caveolin-1. | Manual (Western-based) | MHCC97L | Homo sapiens | 2019-02-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00230 | PSMD14 | Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizingSNAIL in human esophageal squamous cell carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-01-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00231 | STAMBPL1 | Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cellsby promoting XIAP degradation. | Manual (Western-based) | PC3 | Homo sapiens | 2019-04-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00232 | STAMBPL1 | Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation. | Manual (Western-based) | Caki | Homo sapiens | 2019-12-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00233 | STAMBPL1 | Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation. | Manual (Western-based) | Caki | Homo sapiens | 2019-12-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00234 | STAMBP | STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPKsignaling pathway. | Manual (Western-based) | H1 | Homo sapiens | 2021-06-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00235 | STAMBP | High-throughput screening of functional deubiquitinating enzymes in autophagy. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00236 | STAMBP | Agonist-activated glucagon receptors are deubiquitinated at early endosomes bytwo distinct deubiquitinases to facilitate Rab4a-dependent recycling. | Manual (Western-based) | HEK293 | Homo sapiens | 2020-09-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00237 | STAMBP | STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPKsignaling pathway. | Manual (Western-based) | A549 | Homo sapiens | 2021-06-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00238 | STAMBP | AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/lateendosomes. | Manual (Western-based) | HEK293T | Homo sapiens | 2006-12-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00239 | STAMBP | Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. | Manual (Western-based) | HEK293 | Homo sapiens | 2009-08-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00240 | STAMBP | AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. | Manual (Western-based) | HEK294 | Homo sapiens | 2014-07-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00241 | STAMBP | AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. | Manual (Western-based) | HeLa | Homo sapiens | 2010-02-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00242 | STAMBP | AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. | Manual (Western-based) | HeLa | Homo sapiens | 2010-02-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00243 | STAMBP | STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPKsignaling pathway. | Manual (Western-based) | H1299 | Homo sapiens | 2021-06-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00244 | STAMBP | Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosinephosphorylation and decreased deubiquitination by AMSH. | Manual (Western-based) | HEK293 | Homo sapiens | 2012-07-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00245 | STAMBP | The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3inflammasome. | Manual (Western-based) | HEK293 | Homo sapiens | 2020-11-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00246 | UCHL1 | The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermalgrowth factor receptor. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-04-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00247 | UCHL1 | UCHL1 provides diagnostic and antimetastatic strategies due to itsdeubiquitinating effect on HIF-1alpha. | Manual (Western-based) | 293T | Homo sapiens | 2015-01-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00248 | UCHL1 | Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-05-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00249 | UCHL1 | Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizingDDB1-CUL4-mediated ubiquitination of raptor. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-01-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00250 | UCHL1 | Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate OncoproteinThat Promotes TGFbeta-Induced Breast Cancer Metastasis. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00251 | UCHL1 | Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulatinghydrogen peroxide generated via NADPH oxidase 4. | Manual (Western-based) | HeLa | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00252 | UCHL3 | The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing thearyl hydrocarbon receptor. | Manual (Western-based) | H1299 | Homo sapiens | 2020-06-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00253 | UCHL3 | MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00254 | UCHL3 | The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing thearyl hydrocarbon receptor. | Manual (Western-based) | A549 | Homo sapiens | 2020-06-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00255 | UCHL3 | Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity bystabilizing type I-interferon receptor. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-06-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00256 | UCHL3 | A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis inhomologous recombination. | Manual (Western-based) | U2OS | Homo sapiens | 2016-12-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00257 | UCHL3 | The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing thearyl hydrocarbon receptor. | Manual (Western-based) | H358 | Homo sapiens | 2020-06-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00258 | UCHL3 | UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1stabilization. | Manual (Western-based) | BxPC-3 | Homo sapiens | 2019-09-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00259 | UCHL3 | UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate theNF-kappaB pathway. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00260 | UCHL5 | Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activitythrough a deubiquitinating enzyme, UCH37. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-09-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00261 | UCHL5 | The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling bydeubiquitinating Smoothened. | Manual (Western-based) | NIH-3T3 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00262 | UCHL5 | Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation ofWnt signalling. | Manual (Western-based) | HEK293FT | Homo sapiens | 2017-02-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00263 | UCHL5 | The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-betasignalling. | Manual (Western-based) | HEK293 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00264 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFbeta-1 signaling byde-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis. | Manual (Western-based) | HLF | Homo sapiens | 2016-09-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00265 | UCHL5 | Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinomarecurrence, promotes cell migration and invasion via interacting anddeubiquitinating PRP19. | Manual (Western-based) | l-02 | Homo sapiens | 2012-12-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00266 | USP10 | The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. | Manual (Western-based) | CFBE | Homo sapiens | 2009-04-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00267 | USP10 | Deubiquitinase USP10 regulates Notch signaling in the endothelium. | Manual (Western-based) | HUVEC | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00268 | USP10 | USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitateddeubiquitination of NEMO. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-11-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00269 | USP10 | Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-11-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00270 | USP10 | RNF168 and USP10 regulate topoisomerase IIalpha function via opposing effects on its ubiquitylation. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00271 | USP10 | NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associatedmacrophage polarization in colorectal cancer. | Manual (Western-based) | HCT116 | Homo sapiens | 2021-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00272 | USP10 | USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-08-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00273 | USP10 | A specific E3 ligase/deubiquitinase pair modulates TBP protein levels duringmuscle differentiation. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-09-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00274 | USP10 | USP10 regulates p53 localization and stability by deubiquitinating p53. | Manual (Western-based) | HCT116 | Homo sapiens | 2010-01-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00275 | USP10 | The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels andautophagic activity. | Manual (Western-based) | H4 | Homo sapiens | 2021-02-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00276 | USP10 | Oncogene-induced senescence mediated by c-Myc requires USP10 dependentdeubiquitination and stabilization of p14ARF. | Manual (Western-based) | H1299 | Homo sapiens | 2018-02-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00277 | USP10 | USP10 suppresses tumor progression by inhibiting mTOR activation inhepatocellular carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-07-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00278 | USP10 | Deubiquitination and stabilization of T-bet by USP10. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-05-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00279 | USP10 | Deubiquitination and Activation of AMPK by USP10. | Manual (Western-based) | HCT116 | Homo sapiens | 2016-02-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00280 | USP10 | Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. | Manual (Western-based) | HEK293T | Homo sapiens | 2008-07-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00281 | USP10 | USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloidleukemia. | Manual (Western-based) | KBM5 | Homo sapiens | 2019-04-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00282 | USP10 | Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of humanNHE3 regulating its expression and activity. | Manual (Western-based) | Caco-2bbe | Homo sapiens | 2020-10-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00283 | USP10 | The deubiquitinase USP10 regulates KLF4 stability and suppresses lungtumorigenesis. | Manual (Western-based) | H1299 | Homo sapiens | 2019-11-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00284 | USP10 | Ubiquitin-specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutSHomolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage. | Manual (Western-based) | H1299 | Homo sapiens | 2016-03-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00285 | USP10 | USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization tosuppress tumor formation. | Manual (Western-based) | HCT116 | Homo sapiens | 2013-12-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00286 | USP10 | USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway. | Manual (Western-based) | Endometrial stromal cells | Homo sapiens | 2018-10-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00287 | USP10 | TRAF Family Member-associated NF-kappaB Activator (TANK) Inhibits GenotoxicNuclear Factor kappaB Activation by Facilitating Deubiquitinase USP10-dependentDeubiquitination of TRAF6 Ligase. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00288 | USP10 | USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ. | Manual (Western-based) | HEK293FT | Homo sapiens | 2020-03-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00289 | USP10 | USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ. | Manual (Western-based) | HEK293FT | Homo sapiens | 2020-03-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00290 | USP10 | USP10 regulates Musashi-2 stability via deubiquitination and promotes tumourproliferation in colon cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-01-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00291 | USP10 | The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancerlacking wild-type p53. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00292 | USP10 | Ubiquitin-specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutSHomolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage. | Manual (Western-based) | A549 | Homo sapiens | 2016-03-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00293 | USP10 | Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasisthrough deubiquitinating and stabilizing Smad4 protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-11-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00294 | USP10 | Inhibition of the deubiquitinase USP10 induces degradation of SYK. | Manual (Western-based) | MOLM14 | Homo sapiens | 2020-02-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00295 | USP11 | BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinatingenzyme that exhibits prosurvival function in the cellular response to DNA damage. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00296 | USP11 | USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-01-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00297 | USP11 | The regulation of NONO by USP11 via deubiquitination is linked to theproliferation of melanoma cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-12-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00298 | USP11 | USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediatedactivation of ERK/MAPK signaling pathway. | Manual (Western-based) | HCT116 | Homo sapiens | 2019-09-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00299 | USP11 | USP11-dependent selective cIAP2 deubiquitylation and stabilization determinesensitivity to Smac mimetics. | Manual (Western-based) | HEK293FT | Homo sapiens | 2015-01-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00300 | USP11 | The regulation of NONO by USP11 via deubiquitination is linked to theproliferation of melanoma cells. | Manual (Western-based) | A375 | Homo sapiens | 2020-12-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00301 | USP11 | USP11 regulates p53 stability by deubiquitinating p53. | Manual (Western-based) | U2-OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00302 | USP11 | The regulation of NONO by USP11 via deubiquitination is linked to theproliferation of melanoma cells. | Manual (Western-based) | SK-MEL-28 | Homo sapiens | 2020-12-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00303 | USP11 | De-ubiquitinating enzyme, USP11, promotes transforming growth factor beta-1signaling through stabilization of transforming growth factor beta receptor II. | Manual (Western-based) | MRC5 | Homo sapiens | 2016-11-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00304 | USP11 | Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion ofTumorigenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-12-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00305 | USP11 | TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Statusof Squamous Cell Carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00306 | USP11 | Usp11 controls cortical neurogenesis and neuronal migration through Sox11stabilization. | Manual (Western-based) | N2a | Homo sapiens | 2021-02-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00307 | USP11 | USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00308 | USP11 | Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycleprogression and DNA damage responses. | Manual (Western-based) | HCT116 | Homo sapiens | 2018-04-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00309 | USP11 | The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00310 | USP11 | Usp11 controls cortical neurogenesis and neuronal migration through Sox11stabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00311 | USP11 | USP11 degrades KLF4 via its deubiquitinase activity in liver diseases. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-06-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00312 | USP11 | USP11 augments TGFbeta signalling by deubiquitylating ALK5. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00313 | USP11 | Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4atumour suppressor. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-07-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00314 | USP11 | USP11 regulates p53 stability by deubiquitinating p53. | Manual (Western-based) | H1299 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00315 | USP11 | USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediatedactivation of ERK/MAPK signaling pathway. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00316 | USP11 | Upregulation of USP11 promotes epithelialtomesenchymal transition bydeubiquitinating Snail in ovarian cancer. | Manual (Western-based) | OVCAR-3 | Homo sapiens | 2018-12-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00317 | USP11 | USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-01-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00318 | USP11 | Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expressionand activate lung epithelial cells. | Manual (Western-based) | A549 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00319 | USP11 | Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formationfor sustained oncogenic translation in DLBCL. | Manual (Western-based) | SUDHL6 | Homo sapiens | 2018-02-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00320 | USP11 | USP11 regulates PML stability to control Notch-induced malignancy in braintumours. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00321 | USP11 | Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor throughdeubiquitinating and stabilizing VGLL4 protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-12-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00322 | USP12 | USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizingBCL10. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00323 | USP12 | Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation byUSP12. | Manual (Western-based) | LNCaP | Homo sapiens | 2018-05-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00324 | USP12 | Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor. | Manual (Western-based) | COS-7 | Homo sapiens | 2013-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00325 | USP12 | The ubiquitin-specific protease 12 (USP12) is a negative regulator of notchsignaling acting on notch receptor trafficking toward degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-07-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00326 | USP12 | WD repeat protein WDR48 in complex with deubiquitinase USP12 suppressesAkt-dependent cell survival signaling by stabilizing PH domain leucine-richrepeat protein phosphatase 1 (PHLPP1). | Manual (Western-based) | HCT116 | Homo sapiens | 2013-10-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00327 | USP13 | Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. | Manual (Western-based) | HeLa | Homo sapiens | 2020-11-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00328 | USP13 | USP13 regulates the replication stress response by deubiquitinating TopBP1. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00329 | USP13 | USP13 interacts with cohesin and regulates its ubiquitination in human cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-12-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00330 | USP13 | Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth andMetastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation PrimaryResponse Gene 88/Nuclear Factor-kappaB Pathway in Hepatocellular Carcinoma. | Manual (Western-based) | HEP3B | Homo sapiens | 2020-10-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00331 | USP13 | Beclin1 controls the levels of p53 by regulating the deubiquitination activity ofUSP10 and USP13. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00332 | USP13 | USP13 controls the stability of Aurora B impacting progression through the cellcycle. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-08-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00333 | USP13 | Deubiquitylation and stabilization of PTEN by USP13. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-11-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00334 | USP13 | USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-01-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00335 | USP13 | USP13 enzyme regulates Siah2 ligase stability and activity via noncatalyticubiquitin-binding domains. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-06-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00336 | USP13 | Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-11-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00337 | USP13 | Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimeticinhibitors. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-01-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00338 | USP13 | Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-08-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00339 | USP13 | Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizingFBXL14-mediated Myc ubiquitination. | Manual (Western-based) | GSC | Homo sapiens | 2016-12-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00340 | USP13 | The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00341 | USP13 | Regulation of MITF stability by the USP13 deubiquitinase. | Manual (Western-based) | 501mel | Homo sapiens | 2011-08-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00342 | USP13 | Deubiquitinase USP13 promotes extracellular matrix expression by stabilizingSmad4 in lung fibroblast cells. | Manual (Western-based) | MRC5 | Homo sapiens | 2020-05-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00343 | USP13 | Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy throughDeubiquitinating VPS34. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00344 | USP13 | USP13 negatively regulates antiviral responses by deubiquitinating STING. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-05-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00345 | USP13 | USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. | Manual (Western-based) | EFO-27 | Homo sapiens | 2017-06-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00346 | USP14 | Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-MediatedSignaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-BindingProtein 2 and Beclin 1. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-12-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00347 | USP14 | Reversible ubiquitination shapes NLRC5 function and modulates NF-kappaBactivation switch. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-11-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00348 | USP14 | TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses. | Manual (Western-based) | HeLa | Homo sapiens | 2016-09-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00349 | USP14 | CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breastcancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-08-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00350 | USP14 | TRIM14 Promotes Noncanonical NF-kappaB Activation by Modulating p100/p52Stability via Selective Autophagy. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-11-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00351 | USP14 | Ubiquitin-specific protease 14 regulates ovarian cancer cisplatin-resistance bystabilizing BCL6 oncoprotein. | Manual (Western-based) | A2780 | Homo sapiens | 2020-02-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00352 | USP14 | Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination. | Manual (Western-based) | MDA-MB-453 | Homo sapiens | 2018-01-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00353 | USP14 | Ubiquitin-specific protease 14 promotes prostate cancer progression throughdeubiquitinating the transcriptional factor ATF2. | Manual (Western-based) | PC3 | Homo sapiens | 2020-01-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00354 | USP14 | The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-InducedCell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B. | Manual (Western-based) | U-937 | Homo sapiens | 2017-06-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00355 | USP14 | BECN1 promotes the migration of NSCLC cells through regulating the ubiquitinationof Vimentin. | Manual (Western-based) | H1299 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00356 | USP14 | Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-MediatedSignaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-BindingProtein 2 and Beclin 1. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-12-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00357 | USP14 | Lidocaine inhibits the proliferation and invasion of hepatocellular carcinoma by downregulating USP14 induced PI3K/Akt pathway. | Manual (Western-based) | Huh-7 | Homo sapiens | 2020-04-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00358 | USP14 | USP14 negatively regulates RIG-I-mediated IL-6 and TNF-alpha production byinhibiting NF-kappaB activation. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-12-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00359 | USP14 | Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-08-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00360 | USP14 | Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminalhydrolase 14 (USP14) is critical for NSCLC migration. | Manual (Western-based) | H1299 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00361 | USP14 | USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00362 | USP14 | Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinatedproteins in mammalian cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00363 | USP15 | USP15 negatively regulates Nrf2 through deubiquitination of Keap1. | Manual (Western-based) | MDA-MB-231 | Homo sapiens | 2013-05-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00364 | USP15 | USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting theproteasome gene expression. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-07-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00365 | USP15 | USP15 promotes the apoptosis of degenerative nucleus pulposus cells bysuppressing the PI3K/AKT signalling pathway. | Manual (Western-based) | Degenerative NP | Homo sapiens | 2020-11-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00366 | USP15 | MEKK2 mediates an alternative beta-catenin pathway that promotes bone formation. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-02-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00367 | USP15 | USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-09-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00368 | USP15 | Ubiquitin-Specific Protease 15 Maintains Transforming Growth Factor-beta Pathway Activity by Deubiquitinating Transforming Growth Factor-beta Receptor I duringWound Healing. | Manual (Western-based) | HDFs | Homo sapiens | 2019-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00369 | USP15 | USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and MaintainsCerebellar Homeostasis. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00370 | USP15 | The nucleolar protein GLTSCR2 is required for efficient viral replication. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00371 | USP15 | USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin Receptor-MediatedSignaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00372 | USP15 | The deubiquitinating enzyme USP15 stabilizes ERalpha and promotes breast cancerprogression. | Manual (Western-based) | MCF-7 | Homo sapiens | 2021-03-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00373 | USP15 | USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. | Manual (Western-based) | U2-OS | Homo sapiens | 2020-09-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00374 | USP15 | USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2ubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-01-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00375 | USP15 | Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-06-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00376 | USP15 | CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. | Manual (Western-based) | HeLa | Homo sapiens | 2007-02-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00377 | USP15 | The deubiquitinating enzyme USP15 stabilizes ERalpha and promotes breast cancerprogression. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-03-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00378 | USP15 | USP15 Enhances Re-epithelialization Through Deubiquitinating EIF4A1 DuringCutaneous Wound Repair. | Manual (Western-based) | HaCaT | Homo sapiens | 2020-06-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00379 | USP15 | The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signalingby deubiquitylating TRIM25. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-01-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00380 | USP15 | USP15 is a deubiquitylating enzyme for receptor-activated SMADs. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-09-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00381 | USP15 | USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-10-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00382 | USP15 | Ubiquitination of RORgammat at Lysine 446 Limits Th17 Differentiation byControlling Coactivator Recruitment. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-07-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00383 | USP15 | The deubiquitinating enzyme USP15 stabilizes ERalpha and promotes breast cancerprogression. | Manual (Western-based) | T47D | Homo sapiens | 2021-03-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00384 | USP16 | USP16-mediated deubiquitination of calcineurin A controls peripheral T cellmaintenance. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-05-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00385 | USP16 | USP16-mediated deubiquitination of calcineurin A controls peripheral T cellmaintenance. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-05-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00386 | USP16 | USP16 regulates castration-resistant prostate cancer cell proliferation bydeubiquitinating and stablizing c-Myc. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-02-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00387 | USP16 | Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmuneinflammation. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-01-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00388 | USP17L2 | Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. | Manual (Western-based) | HeLa | Homo sapiens | 2011-01-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00389 | USP17L2 | USP17- and SCFbetaTrCP--regulated degradation of DEC1 controls the DNA damageresponse. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-09-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00390 | USP17L2 | The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizingthe methyltransferase SET8 and transcriptionally repressing p21. | Manual (Western-based) | COS-7 | Homo sapiens | 2019-09-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00391 | USP17L2 | USP17 is upregulated in osteosarcoma and promotes cell proliferation, metastasis,and epithelial-mesenchymal transition through stabilizing SMAD4. | Manual (Western-based) | U2-OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00392 | USP17L2 | The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-relatedorphan nuclear receptor gammat (RORgammat) in Th17 cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-07-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00393 | USP17L2 | USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smokeextract-induced inflammation. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-09-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00394 | USP17L2 | The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 anddifferentially affect its function. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-06-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00395 | USP17L2 | The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-11-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00396 | USP17L2 | The ubiquitin-specific protease 17 is involved in virus-triggered type I IFNsignaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-04-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00397 | USP17L2 | USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2009-02-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00398 | USP17L2 | Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-01-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00399 | USP17L2 | USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-01-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00400 | USP17L2 | De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression andcell proliferation. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00401 | USP18 | USP18 directly regulates Snail1 protein through ubiquitination pathway incolorectal cancer. | Manual (Western-based) | SW480 | Homo sapiens | 2020-07-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00402 | USP18 | USP18 deubiquitinates and stabilizes Twist1 to promote epithelial-mesenchymaltransition in glioblastoma cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-04-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00403 | USP18 | USP18 positively regulates innate antiviral immunity by promoting K63-linkedpolyubiquitination of MAVS. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-05-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00404 | USP18 | USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation bydeubiquitinating the TAK1-TAB1 complex. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-07-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00405 | USP18 | USP18 recruits USP20 to promote innate antiviral response throughdeubiquitinating STING/MITA. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00406 | USP18 | USP18 protects against hepatic steatosis and insulin resistance through itsdeubiquitinating activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-10-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00407 | USP18 | USP18 directly regulates Snail1 protein through ubiquitination pathway incolorectal cancer. | Manual (Western-based) | DLD1 | Homo sapiens | 2020-07-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00408 | USP18 | Deubiquitinase USP18 regulates reactive astrogliosis by stabilizing SOX9. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-03-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00409 | USP19 | USP19 suppresses cellular type I interferon signaling by targeting TRAF3 fordeubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00410 | USP19 | USP19 modulates autophagy and antiviral immune responses by deubiquitinatingBeclin-1. | Manual (Western-based) | HeLa | Homo sapiens | 2016-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00411 | USP19 | USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and controlchromosomal stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00412 | USP19 | USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 UbiquitinLigase. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00413 | USP19 | Ubiquitin specific protease 19 involved in transcriptional repression of retinoicacid receptor by stabilizing CORO2A. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00414 | USP19 | USP19 suppresses inflammation and promotes M2-like macrophage polarization bymanipulating NLRP3 function via autophagy. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00415 | USP19 | Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligaseMARCH6. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-08-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00416 | USP19 | Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6. | Manual (Western-based) | HeLa | Homo sapiens | 2016-10-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00417 | USP19 | Regulation of TRIF-mediated innate immune response by K27-linkedpolyubiquitination and deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00418 | USP19 | USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth. | Manual (Western-based) | A673 | Homo sapiens | 2019-01-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00419 | USP1 | USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program inosteosarcoma. | Manual (Western-based) | U2-OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00420 | USP1 | USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1. | Manual (Western-based) | MHCC-97H | Homo sapiens | 2020-09-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00421 | USP1 | USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviralresponses. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-11-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00422 | USP1 | USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellularcompartmentalization and autophagy. | Manual (Western-based) | U2-OS | Homo sapiens | 2018-10-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00423 | USP1 | A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancerprogression and castration resistance. | Manual (Western-based) | PC-3 | Homo sapiens | 2021-06-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00424 | USP1 | Aberrant Activation of beta-Catenin Signaling Drives Glioma Tumorigenesis viaUSP1-Mediated Stabilization of EZH2. | Manual (Western-based) | GSC11 | Homo sapiens | 2018-11-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00425 | USP1 | UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation bypromoting NLRP3 expression. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-11-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00426 | USP1 | USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1. | Manual (Western-based) | PLC/PRF/5 | Homo sapiens | 2020-09-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00427 | USP1 | Ubiquitin specific peptidase 1 promotes hepatic fibrosis through positiveregulation of CXCL1 by deubiquitinating SNAIL. | Manual (Western-based) | LX-2 | Homo sapiens | 2021-04-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00428 | USP1 | USP1 links platinum resistance to cancer cell dissemination by regulating Snailstability. | Manual (Western-based) | 293T/17 | Homo sapiens | 2019-05-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00429 | USP1 | USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis. | Manual (Western-based) | MCF7 | Homo sapiens | 2018-12-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00430 | USP20 | USP20 positively regulates tumorigenesis and chemoresistance through beta-cateninstabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-06-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00431 | USP20 | Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3Stability and Biological Activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-04-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00432 | USP20 | USP18 recruits USP20 to promote innate antiviral response throughdeubiquitinating STING/MITA. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00433 | USP20 | HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-10-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00434 | USP20 | The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptorrecycling and resensitization. | Manual (Western-based) | HEK293T | Homo sapiens | 2009-05-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00435 | USP20 | Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1phosphorylation and DNA repair by homologous recombination. | Manual (Western-based) | U2-OS | Homo sapiens | 2014-06-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00436 | USP20 | The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagyinitiation. | Manual (Western-based) | HeLa | Homo sapiens | 2018-02-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00437 | USP20 | The Deubiquitinating Enzyme USP20 Regulates the TNFalpha-Induced NF-kappaBSignaling Pathway through Stabilization of p62. | Manual (Western-based) | HeLa | Homo sapiens | 2020-04-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00438 | USP20 | Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virustype 1 tax to negatively regulate NF-kappaB signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-04-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00439 | USP21 | USP21 regulates Hippo pathway activity by mediating MARK protein turnover. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-07-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00440 | USP21 | Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-inducednuclear factor kappaB activation via binding to and deubiquitinatingreceptor-interacting protein 1. | Manual (Western-based) | HEK293T | Homo sapiens | 2009-11-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00441 | USP21 | USP21 deubiquitylates Nanog to regulate protein stability and stem cellpluripotency. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00442 | USP21 | FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and PaclitaxelSensitivity in Basal-like Breast Cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00443 | USP21 | The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, andinvasion of non-small-cell lung cancer. | Manual (Western-based) | LC | Homo sapiens | 2020-01-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00444 | USP21 | USP21 modulates Goosecoid function through deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-07-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00445 | USP21 | USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathwayactivation. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00446 | USP21 | USP21 prevents the generation of T-helper-1-like Treg cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-11-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00447 | USP21 | Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21)as a positive regulator of the transcription factor GATA3. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-02-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00448 | USP21 | The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00449 | USP21 | Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting asa Fra-1 Deubiquitinase. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-01-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00450 | USP21 | USP21 negatively regulates antiviral response by acting as a RIG-Ideubiquitinase. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-02-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00451 | USP21 | p38 inhibition provides anti-DNA virus immunity by regulation of USP21phosphorylation and STING activation. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00452 | USP21 | Deubiquitination and stabilization of IL-33 by USP21. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-07-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00453 | USP22 | Nuclear GSK3beta promotes tumorigenesis by phosphorylating KDM1A and inducing itsdeubiquitylation by USP22. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00454 | USP22 | Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. | Manual (Western-based) | HCT116 | Homo sapiens | 2015-10-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00455 | USP22 | CRISPR screen in regulatory T cells reveals modulators of Foxp3. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-04-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00456 | USP22 | USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation througha PU.1-dependent mechanism. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00457 | USP22 | USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 innon-small cell lung cancer. | Manual (Western-based) | A549 | Homo sapiens | 2015-03-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00458 | USP22 | Ubiquitin-specific protease 22 acts as an oncoprotein to maintain gliomamalignancy through deubiquitinating B cell-specific Moloney murine leukemia virusintegration site 1 for stabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-06-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00459 | USP22 | Ubiquitin-specific protease 22 ameliorates chronic alcohol-associated liverdisease by regulating BRD4. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-04-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00460 | USP22 | Deubiquitinating enzyme USP22 positively regulates c-Myc stability andtumorigenic activity in mammalian and breast cancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00461 | USP22 | USP22 positively modulates ERalpha action via its deubiquitinase activity inbreast cancer. | Manual (Western-based) | MCF-7 | Homo sapiens | 2020-06-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00462 | USP22 | Deubiquitinating enzyme USP22 positively regulates c-Myc stability andtumorigenic activity in mammalian and breast cancer cells. | Manual (Western-based) | MCF-7 | Homo sapiens | 2017-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00463 | USP22 | USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by aHIF1alpha/USP22 positive feedback loop upon TP53 inactivation. | Manual (Western-based) | PLC/PRF/5 | Homo sapiens | 2019-11-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00464 | USP22 | Deubiquitinating enzyme USP22 positively regulates c-Myc stability andtumorigenic activity in mammalian and breast cancer cells. | Manual (Western-based) | T-47D | Homo sapiens | 2017-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00465 | USP22 | USP22 regulates cell proliferation by deubiquitinating the transcriptionalregulator FBP1. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-09-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00466 | USP22 | Ubiquitin-specific peptidase USP22 negatively regulates the STAT signalingpathway by deubiquitinating SIRT1. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-06-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00467 | USP22 | USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. | Manual (Western-based) | A375 | Homo sapiens | 2021-03-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00468 | USP22 | USP22 is a positive regulator of NFATc2 on promoting IL2 expression. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-02-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00469 | USP22 | miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1stabilization and promoting p21 expression. | Manual (Western-based) | HOS | Homo sapiens | 2021-02-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00470 | USP22 | USP22 deficiency in melanoma mediates resistance to T cells throughIFNgamma-JAK1-STAT1 signal axis. | Manual (Western-based) | Lenti-X 293 | Homo sapiens | 2021-02-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00471 | USP22 | USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin. | Manual (Western-based) | ACHN | Homo sapiens | 2020-09-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00472 | USP22 | Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00473 | USP22 | USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity. | Manual (Western-based) | HepG2 | Homo sapiens | 2019-08-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00474 | USP22 | The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells. | Manual (Western-based) | HEK293FT | Homo sapiens | 2020-07-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00475 | USP22 | The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells. | Manual (Western-based) | HEK293FT | Homo sapiens | 2020-07-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00476 | USP24 | USP24 stabilizes bromodomain containing proteins to promote lung cancermalignancy. | Manual (Western-based) | H1299 | Homo sapiens | 2020-11-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00477 | USP24 | USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 andbeta-TrCP and promotes cancer malignancy. | Manual (Western-based) | M2 macrophage | Homo sapiens | 2018-09-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00478 | USP24 | USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 andbeta-TrCP and promotes cancer malignancy. | Manual (Western-based) | A549 | Homo sapiens | 2018-09-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00479 | USP25 | Ubiquitin-specific proteases 25 negatively regulates virus-induced type Iinterferon signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-11-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00480 | USP25 | Ubiquitin-specific proteases 25 negatively regulates virus-induced type Iinterferon signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-11-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00481 | USP25 | Ubiquitin-specific proteases 25 negatively regulates virus-induced type Iinterferon signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-11-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00482 | USP25 | Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associateddegradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-05-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00483 | USP25 | Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic ChaperoninTRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25. | Manual (Western-based) | SH-SY5Y | Homo sapiens | 2015-03-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00484 | USP25 | Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responsesthrough deubiquitination of the adaptor protein TRAF3. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-05-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00485 | USP25 | LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcriptionin THP-1 cells. | Manual (Western-based) | THP-1 | Homo sapiens | 2018-08-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00486 | USP25 | Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensuresproliferation of Ph-positive leukemia cells. | Manual (Western-based) | K562 | Homo sapiens | 2020-03-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00487 | USP25 | Negative regulation of IL-17-mediated signaling and inflammation by theubiquitin-specific protease USP25. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-10-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00488 | USP25 | Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associateddegradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-05-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00489 | USP25 | Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associateddegradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-05-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00490 | USP25 | Negative regulation of IL-17-mediated signaling and inflammation by theubiquitin-specific protease USP25. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-10-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00491 | USP26 | The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligaseMdm2. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-10-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00492 | USP26 | Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to SuppressProstate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through AlteringARv7 Protein Degradation. | Manual (Western-based) | C4-2 | Homo sapiens | 2020-03-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00493 | USP26 | USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00494 | USP26 | USP26 regulates TGF-beta signaling by deubiquitinating and stabilizing SMAD7. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-04-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00495 | USP26 | USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-08-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00496 | USP27X | Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS toRegulate Cytosolic DNA-Mediated Signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00497 | USP27X | USP27-mediated Cyclin E stabilization drives cell cycle progression andhepatocellular tumorigenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00498 | USP27X | TGFbeta-Activated USP27X Deubiquitinase Regulates Cell Migration andChemoresistance via Stabilization of Snail1. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-10-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00499 | USP27X | USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-02-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00500 | USP28 | A role for the deubiquitinating enzyme USP28 in control of the DNA-damageresponse. | Manual (Western-based) | H460 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00501 | USP28 | Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growthin non-small-cell lung cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00502 | USP28 | Usp28 counteracts Fbw7 in intestinal homeostasis and cancer. | Manual (Western-based) | HCT116 | Homo sapiens | 2015-02-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00503 | USP28 | Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidinekinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant humanleukemia cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00504 | USP28 | Maintaining protein stability of Np63 via USP28 is required by squamous cancercells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-03-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00505 | USP28 | CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion,and lung metastasis of human bladder cancer (BC) cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-01-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00506 | USP28 | The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-03-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00507 | USP28 | The stability and oncogenic function of LIN28A are regulated by USP28. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-12-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00508 | USP28 | The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits tobreast cancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-09-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00509 | USP28 | The ubiquitin-specific protease USP28 is required for MYC stability. | Manual (Western-based) | HeLa | Homo sapiens | 2007-06-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00510 | USP29 | Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-05-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00511 | USP29 | Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's DiseasePatients. | Manual (Western-based) | SH-SY5Y | Homo sapiens | 2019-12-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00512 | USP29 | Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating withphosphatase SCP1 to stabilize Snail protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-09-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00513 | USP29 | USP29 maintains the stability of cGAS and promotes cellular antiviral responsesand autoimmunity. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00514 | USP29 | USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-03-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00515 | USP2 | Regulation of behavioral circadian rhythms and clock protein PER1 by thedeubiquitinating enzyme USP2. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-06-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00516 | USP2 | Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-03-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00517 | USP2 | De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-12-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00518 | USP2 | De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-05-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00519 | USP2 | USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 inresponse to inflammatory signals. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-06-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00520 | USP2 | USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability. | Manual (Western-based) | M1 | Homo sapiens | 2013-03-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00521 | USP2 | Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnalglucose metabolism through 11beta-hydroxysteroid dehydrogenase 1. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-03-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00522 | USP2 | USP2a Supports Metastasis by Tuning TGF-beta Signaling. | Manual (Western-based) | MLF | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00523 | USP2 | USP2a negatively regulates IL-1beta- and virus-induced NF-kappaB activation bydeubiquitinating TRAF6. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-05-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00524 | USP2 | Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizesbeta-catenin. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-09-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00525 | USP2 | Ubiquitin-specific protease 2b negatively regulates IFN-beta production andantiviral activity by targeting TANK-binding kinase 1. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-07-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00526 | USP2 | Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability ofAurora-A. | Manual (Western-based) | H1299 | Homo sapiens | 2011-09-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00527 | USP2 | Deubiquitinase USP2a Sustains Interferons Antiviral Activity by RestrictingUbiquitination of Activated STAT1 in the Nucleus. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-07-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00528 | USP2 | Suppression of cancer cell growth by promoting cyclin D1 degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00529 | USP2 | The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. | Manual (Western-based) | H1299 | Homo sapiens | 2007-02-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00530 | USP2 | Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3ligase and USP2 deubiquitinating enzyme. | Manual (Western-based) | HEK293T | Homo sapiens | 2011-02-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00531 | USP2 | Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-ElicitedExpression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-09-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00532 | USP2 | The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFRdegradation. | Manual (Western-based) | HeLa | Homo sapiens | 2012-06-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00533 | USP2 | The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting theE3-Ubiquitin Ligase IDOL. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-12-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00534 | USP2 | Ubiquitin-specific protease USP2-45 acts as a molecular switch to promotealpha2delta-1-induced downregulation of Cav1.2 channels. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-11-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00535 | USP2 | Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activationof the CLOCK/BMAL1 complex. | Manual (Western-based) | NIH 3T3 | Homo sapiens | 2008-07-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00536 | USP2 | MdmX is a substrate for the deubiquitinating enzyme USP2a. | Manual (Western-based) | H1299 | Homo sapiens | 2009-10-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00537 | USP2 | Suppression of cancer cell growth by promoting cyclin D1 degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00538 | USP30 | The IKKbeta-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-11-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00539 | USP30 | USP30 protects against oxygen-glucose deprivation/reperfusion inducedmitochondrial fragmentation and ubiquitination and degradation of MFN2. | Manual (Western-based) | SK-N-BE | Homo sapiens | 2021-02-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00540 | USP30 | Amplification of Glyceronephosphate O-Acyltransferase and Recruitment of USP30Stabilize DRP1 to Promote Hepatocarcinogenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-08-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00541 | USP32 | USP32 regulates late endosomal transport and recycling through deubiquitylationof Rab7. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-03-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00542 | USP33 | USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-08-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00543 | USP33 | Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis viastabilising the phosphatase DUSP1 in prostate cancer. | Manual (Western-based) | C4-2B | Homo sapiens | 2019-12-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00544 | USP33 | USP33 regulates centrosome biogenesis via deubiquitination of the centriolarprotein CP110. | Manual (Western-based) | HeLa | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00545 | USP33 | Agonist-activated glucagon receptors are deubiquitinated at early endosomes bytwo distinct deubiquitinases to facilitate Rab4a-dependent recycling. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-09-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00546 | USP33 | The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptorrecycling and resensitization. | Manual (Western-based) | COS | Homo sapiens | 2009-05-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00547 | USP33 | VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00548 | USP33 | Ubiquitin-specific protease USP34 controls osteogenic differentiation and boneformation by regulating BMP2 signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-09-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00549 | USP33 | Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis viastabilising the phosphatase DUSP1 in prostate cancer. | Manual (Western-based) | PC3 | Homo sapiens | 2019-12-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00550 | USP33 | The deubiquitylase USP33 discriminates between RALB functions in autophagy andinnate immune response. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-09-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00551 | USP33 | Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to ActivateHuman Microglial Cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-08-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00552 | USP33 | Radiation Enhances the Epithelial- Mesenchymal Transition of A549 Cells viamiR3591-5p/USP33/PPM1A. | Manual (Western-based) | A549 | Homo sapiens | 2018-10-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00553 | USP34 | The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 fromproteasomal degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-12-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00554 | USP34 | The deubiquitinase USP34 stabilizes SOX2 and induces cell survival and drugresistance in laryngeal squamous cell carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-08-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00555 | USP34 | The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNAdouble-strand breaks. | Manual (Western-based) | HeLa | Homo sapiens | 2013-07-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00556 | USP34 | Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-kappaB Signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00557 | USP34 | USP34 regulates tooth root morphogenesis by stabilizing NFIC. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-03-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00558 | USP35 | USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaBactivation through stabilization of ABIN-2. | Manual (Western-based) | H1299 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00559 | USP35 | Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovariancancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-07-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00560 | USP35 | Deubiquitinase USP35 modulates ferroptosis in lung cancer via targetingferroportin. | Manual (Western-based) | Lung cancer cells | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00561 | USP35 | USP35 regulates mitotic progression by modulating the stability of Aurora B. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-02-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00562 | USP35 | USP35, regulated by estrogen and AKT, promotes breast tumorigenesis bystabilizing and enhancing transcriptional activity of estrogen receptor alpha. | Manual (Western-based) | HEK293T17 | Homo sapiens | 2021-06-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00563 | USP36 | Nucleolar structure and function are regulated by the deubiquitylating enzymeUSP36. | Manual (Western-based) | COS-7 | Homo sapiens | 2009-02-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00564 | USP36 | USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Mycand SOD2. | Manual (Western-based) | HK-2 | Homo sapiens | 2019-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00565 | USP36 | MELK mediates the stability of EZH2 through site-specific phosphorylation inextranodal natural killer/T-cell lymphoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00566 | USP36 | Nucleolar structure and function are regulated by the deubiquitylating enzymeUSP36. | Manual (Western-based) | COS-7 | Homo sapiens | 2009-02-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00567 | USP36 | PME-1 is regulated by USP36 in ERK and Akt signaling pathways. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-04-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00568 | USP36 | Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causespreimplantation lethality in mice. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-12-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00569 | USP36 | Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressedDevelopmentally Down-regulated 4-2 (Nedd4-2) Actions over the NeurotrophinReceptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). | Manual (Western-based) | HEK293T | Homo sapiens | 2016-07-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00570 | USP36 | The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizesc-Myc. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-03-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00571 | USP36 | The deubiquitinase USP36 Regulates DNA replication stress and confers therapeuticresistance through PrimPol stabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00572 | USP37 | The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-08-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00573 | USP37 | USP37 promotes deubiquitination of HIF2alpha in kidney cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00574 | USP37 | USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-06-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00575 | USP37 | USP37 is a SNAI1 deubiquitinase. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00576 | USP37 | Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote Sphase entry. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00577 | USP37 | Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3gamma. | Manual (Western-based) | H1299 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00578 | USP37 | USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-10-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00579 | USP38 | USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-09-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00580 | USP38 | The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-06-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00581 | USP38 | The deubiquitinase USP38 affects cellular functions through interacting withLSD1. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-11-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00582 | USP38 | The Deubiquitinase USP38 Promotes NHEJ Repair through Regulation of HDAC1Activity and Regulates Cancer Cell Response to Genotoxic Insults. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00583 | USP38 | USP38 regulates the stemness and chemoresistance of human colorectal cancer viaregulation of HDAC3. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00584 | USP39 | USP39 regulates DNA damage response and chemo-radiation resistance bydeubiquitinating and stabilizing CHK2. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00585 | USP39 | Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1ubiquitination and thereby determine the progression of hepatocellular carcinoma. | Manual (Western-based) | SK-hep-1 | Homo sapiens | 2021-03-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00586 | USP39 | USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type IIFN-Induced Antiviral Immunity. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00587 | USP39 | Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1ubiquitination and thereby determine the progression of hepatocellular carcinoma. | Manual (Western-based) | HepG2 | Homo sapiens | 2021-03-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00588 | USP39 | USP39 regulates DNA damage response and chemo-radiation resistance bydeubiquitinating and stabilizing CHK2. | Manual (Western-based) | A549 | Homo sapiens | 2019-02-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00589 | USP3 | Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion andEpithelial-Mesenchymal Transition via Stabilizing Snail. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-07-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00590 | USP3 | Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppressesIL-1beta induced chondrocyte apoptosis. | Manual (Western-based) | patients' chondrocytes | Homo sapiens | 2019-05-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00591 | USP3 | Ubiquitin-specific protease 3 promotes cell migration and invasion by interactingwith and deubiquitinating SUZ12 in gastric cancer. | Manual (Western-based) | BCG-823 | Homo sapiens | 2019-06-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00592 | USP3 | Smoothened Promotes Glioblastoma Radiation Resistance Via ActivatingUSP3-Mediated Claspin Deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-01-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00593 | USP3 | USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and15. | Manual (Western-based) | HeLa | Homo sapiens | 2013-10-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00594 | USP3 | USP3 stabilizes p53 protein through its deubiquitinase activity. | Manual (Western-based) | U2-OS | Homo sapiens | 2017-08-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00595 | USP3 | USP3 stabilizes p53 protein through its deubiquitinase activity. | Manual (Western-based) | IMR90 | Homo sapiens | 2017-08-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00596 | USP3 | USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-10-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00597 | USP3 | USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5. | Manual (Western-based) | HCC1937 | Homo sapiens | 2019-10-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00598 | USP3 | USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and15. | Manual (Western-based) | HeLa | Homo sapiens | 2013-10-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00599 | USP3 | USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5. | Manual (Western-based) | HCC1806 | Homo sapiens | 2019-10-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00600 | USP3 | Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein inHuman Embryonic Stem Cells. | Manual (Western-based) | NCCIT | Homo sapiens | 2021-05-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00601 | USP3 | Genome-scale screening of deubiquitinase subfamily identifies USP3 as astabilizer of Cdc25A regulating cell cycle in cancer. | Manual (Western-based) | HeLa | Homo sapiens | 2020-05-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00602 | USP3 | An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis througheffects on USP3 and MYCN stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-03-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00603 | USP3 | Smoothened Promotes Glioblastoma Radiation Resistance Via ActivatingUSP3-Mediated Claspin Deubiquitination. | Manual (Western-based) | Recurrent GBM | Homo sapiens | 2020-01-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00604 | USP3 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-likereceptors. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-12-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00605 | USP3 | Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein inHuman Embryonic Stem Cells. | Manual (Western-based) | hESC | Homo sapiens | 2021-05-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00606 | USP3 | Genome-scale screening of deubiquitinase subfamily identifies USP3 as astabilizer of Cdc25A regulating cell cycle in cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00607 | USP3 | Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00608 | USP40 | Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with thede-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in humannon-small cell lung cancer cells. | Manual (Western-based) | HEK293FT | Homo sapiens | 2019-05-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00609 | USP42 | Regulation of p53 stability and function by the deubiquitinating enzyme USP42. | Manual (Western-based) | U2-OS | Homo sapiens | 2011-11-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00610 | USP42 | USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wntsignalling. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-03-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00611 | USP43 | USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer. | Manual (Western-based) | SW480 | Homo sapiens | 2021-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00612 | USP43 | USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer. | Manual (Western-based) | DLD1 | Homo sapiens | 2021-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00613 | USP44 | USP44 suppresses pancreatic cancer progression and overcomes gemcitabineresistance by deubiquitinating FBP1. | Manual (Western-based) | PANC-1 | Homo sapiens | 2019-08-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00614 | USP44 | The deubiquitylating enzyme USP44 counteracts the DNA double-strand breakresponse mediated by the RNF8 and RNF168 ubiquitin ligases. | Manual (Western-based) | U2-OS | Homo sapiens | 2013-04-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00615 | USP44 | USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/beta-catenin pathway via Axin1 deubiquitination. | Manual (Western-based) | HCT116 | Homo sapiens | 2020-04-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00616 | USP44 | USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/beta-catenin pathway via Axin1 deubiquitination. | Manual (Western-based) | HT29 | Homo sapiens | 2020-04-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00617 | USP44 | USP44 positively regulates innate immune response to DNA viruses throughdeubiquitinating MITA. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-01-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00618 | USP44 | The deubiquitinase USP44 promotes Treg function during inflammation by preventingFOXP3 degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-07-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00619 | USP44 | USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 ProteinStabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-01-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00620 | USP46 | Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizingENO1 in human esophageal squamous cell carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-07-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00621 | USP46 | The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination andtrafficking. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-07-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00622 | USP46 | USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway. | Manual (Western-based) | H1299 | Homo sapiens | 2020-09-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00623 | USP46 | UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation bypromoting NLRP3 expression. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-11-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00624 | USP46 | Deubiquitinating enzyme USP46 suppresses the progression of hepatocellularcarcinoma by stabilizing MST1. | Manual (Western-based) | Huh-7 | Homo sapiens | 2021-05-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00625 | USP46 | USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway. | Manual (Western-based) | A549 | Homo sapiens | 2020-09-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00626 | USP46 | The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth ofHPV-Transformed Cancers. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-11-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00627 | USP46 | Deubiquitinating enzyme USP46 suppresses the progression of hepatocellularcarcinoma by stabilizing MST1. | Manual (Western-based) | Hep-3B | Homo sapiens | 2021-05-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00628 | USP47 | Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA. | Manual (Western-based) | HeLa | Homo sapiens | 2020-05-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00629 | USP47 | USP47-mediated deubiquitination and stabilization of YAP contributes to theprogression of colorectal cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00630 | USP47 | USP47 Promotes Tumorigenesis by Negative Regulation of p53 throughDeubiquitinating Ribosomal Protein S2. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00631 | USP47 | USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonisticallyregulate katanin-p60-mediated axonal growth. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00632 | USP47 | Deubiquitinase USP47/UBP64E Regulates beta-Catenin Ubiquitination and Degradationand Plays a Positive Role in Wnt Signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-07-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00633 | USP47 | Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00634 | USP48 | Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity. | Manual (Western-based) | U2-OS | Homo sapiens | 2017-02-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00635 | USP48 | Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-06-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00636 | USP48 | The deubiquitinating enzyme USP48 stabilizes TRAF2 and reducesE-cadherin-mediated adherens junctions. | Manual (Western-based) | Beas2B | Homo sapiens | 2017-09-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00637 | USP49 | USP49 inhibits ischemia-reperfusion-induced cell viability suppression andapoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling. | Manual (Western-based) | AC16 | Homo sapiens | 2018-09-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00638 | USP49 | USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKTsignaling. | Manual (Western-based) | SU86 | Homo sapiens | 2017-03-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00639 | USP49 | USP49 negatively regulates cellular antiviral responses via deconjugatingK63-linked ubiquitination of MITA. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-04-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00640 | USP49 | Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growthby suppressing PI3K/AKT signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-04-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00641 | USP49 | USP49 participates in the DNA damage response by forming a positive feedback loopwith p53. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-05-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00642 | USP4 | The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. | Manual (Western-based) | HEK293T | Homo sapiens | 2005-12-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00643 | USP4 | USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-betatype I receptor. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-06-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00644 | USP4 | Ubiquitin-speci fi c protease 4 promotes metastasis of hepatocellular carcinomaby increasing TGF-beta signaling-induced epithelial-mesenchymal transition. | Manual (Western-based) | HCC | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00645 | USP4 | Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor proteinand promotes its function to facilitate interleukin-4 expression in T helper type2 cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-08-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00646 | USP4 | Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function underinflammation by deubiquitinating and stabilizing RORgammat. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-03-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00647 | USP4 | Ubiquitin-speci fi c protease 4 promotes metastasis of hepatocellular carcinomaby increasing TGF-beta signaling-induced epithelial-mesenchymal transition. | Manual (Western-based) | SK-Hep1 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00648 | USP4 | Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization ofPRL-3 Is Required for Potentiating Colorectal Oncogenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-12-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00649 | USP4 | Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitinationand inhibits TNFalpha-induced cancer cell migration. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00650 | USP4 | Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of MetabolicDysfunctions in Nonalcoholic Fatty Liver Disease in Mice. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00651 | USP4 | Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required forubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitinationand tumor growth. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-08-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00652 | USP4 | Ubiquitin-specific protease 4 promotes hepatocellular carcinoma progression viacyclophilin A stabilization and deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-02-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00653 | USP4 | RNPS1 is modulated by ubiquitin-specific protease 4. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-01-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00654 | USP4 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-12-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00655 | USP4 | Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function underinflammation by deubiquitinating and stabilizing RORgammat. | Manual (Western-based) | Th17 | Homo sapiens | 2015-03-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00656 | USP4 | Ubiquitin specific protease 4 positively regulates the WNT/beta-catenin signalingin colorectal cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-07-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00657 | USP4 | Ubiquitin-specific protease 4 promotes TNF-alpha-induced apoptosis bydeubiquitination of RIP1 in head and neck squamous cell carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-01-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00658 | USP4 | Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization ofPRL-3 Is Required for Potentiating Colorectal Oncogenesis. | Manual (Western-based) | SW480 | Homo sapiens | 2015-12-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00659 | USP4 | Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitinationand inhibits TNFalpha-induced cancer cell migration. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00660 | USP4 | Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptorsignaling and regulates innate immune activation. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-01-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00661 | USP4 | Ubiquitin-specific protease 4 promotes hepatocellular carcinoma progression viacyclophilin A stabilization and deubiquitination. | Manual (Western-based) | MHCC97H | Homo sapiens | 2018-02-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00662 | USP4 | USP4 positively regulates RIG-I-mediated antiviral response throughdeubiquitination and stabilization of RIG-I. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-02-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00663 | USP4 | The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer CellStemness. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-06-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00664 | USP4 | Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00665 | USP4 | The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 anddifferentially affect its function. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-06-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00666 | USP4 | USP4 interacts and positively regulates IRF8 function via K48-linkeddeubiquitination in regulatory T cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-06-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00667 | USP50 | The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulatesinflammasome activation by targeting the ASC adaptor protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-01-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00668 | USP51 | CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependentdeubiquitination mechanism. | Manual (Western-based) | MDA-MB-231 | Homo sapiens | 2020-03-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00669 | USP51 | CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependentdeubiquitination mechanism. | Manual (Western-based) | SUM-159 | Homo sapiens | 2020-03-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00670 | USP51 | Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation. | Manual (Western-based) | C3H10T1/2 | Homo sapiens | 2015-04-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00671 | USP52 | USP52 regulates DNA end resection and chemosensitivity through removinginhibitory ubiquitination from CtIP. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00672 | USP52 | USP52 acts as a deubiquitinase and promotes histone chaperone ASF1Astabilization. | Manual (Western-based) | HeLa | Homo sapiens | 2018-03-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00673 | USP53 | USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma throughFKBP51-AKT1 signaling. | Manual (Western-based) | H1975 | Homo sapiens | 2020-06-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00674 | USP5 | Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00675 | USP5 | Deubiquitinase inhibitor degrasyn suppresses metastasis by targetingUSP5-WT1-E-cadherin signalling pathway in pancreatic ductal adenocarcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00676 | USP5 | PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis. | Manual (Western-based) | HeLa | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00677 | USP5 | Wnt-induced deubiquitination FoxM1 ensures nucleus beta-catenin transactivation. | Manual (Western-based) | U87 | Homo sapiens | 2016-02-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00678 | USP5 | The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth ofmultiple myeloma xenografts in nude mice. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-01-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00679 | USP5 | Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth bystabilizing Tu translation elongation factor. | Manual (Western-based) | HCT116 | Homo sapiens | 2019-05-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00680 | USP5 | PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00681 | USP5 | Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation andmyeloma cell apoptosis. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00682 | USP5 | Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation andmyeloma cell apoptosis. | Manual (Western-based) | RPMI-8226 | Homo sapiens | 2017-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00683 | USP5 | Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviralactivity via targeting SMURF1. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-07-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00684 | USP5 | USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG inhepatocellular carcinoma. | Manual (Western-based) | PLC-PRF-5 | Homo sapiens | 2019-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00685 | USP5 | Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation throughdeubiquitinating HDAC2. | Manual (Western-based) | OVCAR3 | Homo sapiens | 2019-11-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00686 | USP5 | Overexpression of USP5 contributes to tumorigenesis in non-small cell lung cancervia the stabilization of beta-catenin protein. | Manual (Western-based) | A549 | Homo sapiens | 2018-11-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00687 | USP5 | Wnt-induced deubiquitination FoxM1 ensures nucleus beta-catenin transactivation. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-02-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00688 | USP5 | Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth bystabilizing Tu translation elongation factor. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-05-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00689 | USP5 | Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation andmyeloma cell apoptosis. | Manual (Western-based) | LP1 | Homo sapiens | 2017-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00690 | USP5 | Deubiquitinase inhibitor degrasyn suppresses metastasis by targetingUSP5-WT1-E-cadherin signalling pathway in pancreatic ductal adenocarcinoma. | Manual (Western-based) | PANC-1 | Homo sapiens | 2019-12-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00691 | USP6 | The deubiquitinase USP6 affects memory and synaptic plasticity through modulatingNMDA receptor stability. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00692 | USP6 | TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis. | Manual (Western-based) | HeLa | Homo sapiens | 2014-09-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00693 | USP6 | TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis. | Manual (Western-based) | HeLa | Homo sapiens | 2014-09-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00694 | USP6 | Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-12-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00695 | USP6 | Jak1-STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene inTumorigenesis. | Manual (Western-based) | HeLa | Homo sapiens | 2016-07-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00696 | USP6 | USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-05-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00697 | USP7 | HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. | Manual (Western-based) | HEK293T | Homo sapiens | 2008-10-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00698 | USP7 | USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-04-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00699 | USP7 | USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00700 | USP7 | Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-Iinterferon antiviral efficacy by destabilizing SOCS1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00701 | USP7 | USP7 Enforces Heterochromatinization of p53 Target Promoters by ProtectingSUV39H1 from MDM2-Mediated Degradation. | Manual (Western-based) | H1299 | Homo sapiens | 2016-03-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00702 | USP7 | HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-04-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00703 | USP7 | The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00704 | USP7 | The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00705 | USP7 | USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UVradiation-induced DNA damage. | Manual (Western-based) | HeLa | Homo sapiens | 2019-11-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00706 | USP7 | Regulation of the Polycomb protein RING1B ubiquitination by USP7. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-08-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00707 | USP7 | Deubiquitylase USP7 regulates human terminal erythroid differentiation bystabilizing GATA1. | Manual (Western-based) | Erythroblasts | Homo sapiens | 2019-03-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00708 | USP7 | Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated byO-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). | Manual (Western-based) | HEK293T | Homo sapiens | 2015-12-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00709 | USP7 | The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinateNF-kB subunits. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-06-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00710 | USP7 | USP7 inhibits Wnt/beta-catenin signaling through promoting stabilization of Axin. | Manual (Western-based) | YAPC | Homo sapiens | 2019-09-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00711 | USP7 | Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNAmethyltransferase Dnmt1. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00712 | USP7 | Serine Metabolism Regulates YAP Activity Through USP7 in Colon Cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-05-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00713 | USP7 | Regulation of epidermal differentiation through KDF1-mediated deubiquitination ofIKKalpha. | Manual (Western-based) | Keratinocytes | Homo sapiens | 2020-04-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00714 | USP7 | Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates itsstability and activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2007-04-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00715 | USP7 | STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathwayregulation. | Manual (Western-based) | U2-OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00716 | USP7 | Deubiquitination of NF-kappaB by Ubiquitin-Specific Protease-7 promotestranscription. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-12-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00717 | USP7 | Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induceddestabilization of Hdmx and Hdm2. | Manual (Western-based) | U2-OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00718 | USP7 | Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiplemyeloma. | Manual (Western-based) | H1299 | Homo sapiens | 2018-06-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00719 | USP7 | Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of humanNHE3 regulating its expression and activity. | Manual (Western-based) | SK-CO15 | Homo sapiens | 2020-10-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00720 | USP7 | Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neuralprogenitor cells. | Manual (Western-based) | NPC | Homo sapiens | 2011-01-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00721 | USP7 | Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-05-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00722 | USP7 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitizegastric cancer cells to T cells killing. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-11-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00723 | USP7 | Ubiquitin-specific protease 7 accelerates p14(ARF) degradation bydeubiquitinating thyroid hormone receptor-interacting protein 12 and promoteshepatocellular carcinoma progression. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-02-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00724 | USP7 | BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNAdamage. | Manual (Western-based) | MCF-7 | Homo sapiens | 2018-02-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00725 | USP7 | Deubiquitylation and stabilization of ARMC5 by ubiquitin-specific processingprotease 7 (USP7) are critical for RCC proliferation. | Manual (Western-based) | 786-O | Homo sapiens | 2021-02-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00726 | USP7 | ATM-mediated stabilization of ZEB1 promotes DNA damage response andradioresistance through CHK1. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-08-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00727 | USP7 | FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. | Manual (Western-based) | H1299 | Homo sapiens | 2006-09-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00728 | USP7 | HSCARG downregulates NF-kappaB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-05-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00729 | USP7 | Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitincomplex in prostate cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-04-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00730 | USP7 | Deubiquitination of NF-kappaB by Ubiquitin-Specific Protease-7 promotestranscription. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-12-24 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00731 | USP7 | Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumornecrosis factor alpha-induced apoptosis. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-10-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00732 | USP7 | Deubiquitylase USP7 regulates human terminal erythroid differentiation bystabilizing GATA1. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-03-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00733 | USP7 | Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of humanNHE3 regulating its expression and activity. | Manual (Western-based) | Caco-2bbe | Homo sapiens | 2020-10-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00734 | USP7 | ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1adipocytes differentiation. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-07-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00735 | USP7 | A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-05-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00736 | USP7 | Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic andBenzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property andTumorigenesis. | Manual (Western-based) | BEAS-2B | Homo sapiens | 2020-07-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00737 | USP7 | Deubiquitination and stabilization of estrogen receptor alpha byubiquitin-specific protease 7 promotes breast tumorigenesis. | Manual (Western-based) | T47D | Homo sapiens | 2019-09-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00738 | USP7 | USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoteroccupancy. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-04-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00739 | USP7 | Arginine methylation-dependent LSD1 stability promotes invasion and metastasis ofbreast cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00740 | USP7 | Early adipogenesis is regulated through USP7-mediated deubiquitination of thehistone acetyltransferase TIP60. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00741 | USP7 | The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity byModulating Its Binding to Chromatin. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-07-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00742 | USP7 | The ubiquitin E3 ligase MARCH7 is differentially regulated by thedeubiquitylating enzymes USP7 and USP9X. | Manual (Western-based) | HEK293T | Homo sapiens | 2008-04-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00743 | USP7 | USP7 controls Chk1 protein stability by direct deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00744 | USP7 | Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. | Manual (Western-based) | HeLa | Homo sapiens | 2016-05-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00745 | USP7 | USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. | Manual (Western-based) | U2-OS | Homo sapiens | 2009-01-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00746 | USP7 | LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediatedstabilization of beta-catenin. | Manual (Western-based) | HCT116 | Homo sapiens | 2019-09-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00747 | USP7 | The shelterin component TPP1 is a binding partner and substrate for thedeubiquitinating enzyme USP7. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-08-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00748 | USP7 | Annexin-1 regulated by HAUSP is essential for UV-induced damage response. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-02-19 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00749 | USP7 | A feedforward circuit shaped by ECT2 and USP7 contributes to breastcarcinogenesis. | Manual (Western-based) | MCF-7 | Homo sapiens | 2020-08-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00750 | USP7 | The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity byModulating Its Binding to Chromatin. | Manual (Western-based) | LNCaP | Homo sapiens | 2015-07-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00751 | USP7 | Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis. | Manual (Western-based) | A375 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00752 | USP7 | DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. | Manual (Western-based) | MEF | Homo sapiens | 2015-03-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00753 | USP7 | The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-12-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00754 | USP7 | USP7 inhibits Wnt/beta-catenin signaling through promoting stabilization of Axin. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00755 | USP7 | Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNAmethyltransferase Dnmt1. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00756 | USP7 | STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathwayregulation. | Manual (Western-based) | U2-OS | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00757 | USP7 | The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinateNF-kB subunits. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-06-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00758 | USP7 | Deubiquitination and stabilization of estrogen receptor alpha byubiquitin-specific protease 7 promotes breast tumorigenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00759 | USP7 | Upregulation of deubiquitinase USP7 by transcription factor FOXO6 promotes ECprogression via targeting the JMJD3/CLU axis. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-12-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00760 | USP7 | HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damageresponse. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-08-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00761 | USP7 | Deubiquitination and stabilization of estrogen receptor alpha byubiquitin-specific protease 7 promotes breast tumorigenesis. | Manual (Western-based) | T47D | Homo sapiens | 2019-09-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00762 | USP7 | USP7 regulates ALS-associated proteotoxicity and quality control through theNEDD4L-SMAD pathway. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-10-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00763 | USP7 | USP7 stabilizes EZH2 and enhances cancer malignant progression. | Manual (Western-based) | HeLa | Homo sapiens | 2020-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00764 | USP7 | The ubiquitin ligase RNF220 enhances canonical Wnt signaling throughUSP7-mediated deubiquitination of beta-catenin. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-09-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00765 | USP7 | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-04-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00766 | USP7 | USP7 stabilizes EZH2 and enhances cancer malignant progression. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-01-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00767 | USP7 | USP7 promotes proliferation of papillary thyroid carcinoma cells throughTBX3-mediated p57(KIP2) repression. | Manual (Western-based) | Bcpap | Homo sapiens | 2020-09-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00768 | USP7 | USP7 promotes proliferation of papillary thyroid carcinoma cells throughTBX3-mediated p57(KIP2) repression. | Manual (Western-based) | 8505c | Homo sapiens | 2020-09-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00769 | USP7 | USP7 regulates the stability and function of HLTF through deubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00770 | USP7 | The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 bymodulating its stability in response to toxic metal exposure. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-04-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00771 | USP7 | The miRNA-15b/USP7/KDM6B axis engages in the initiation of osteoporosis bymodulating osteoblast differentiation and autophagy. | Manual (Western-based) | Osteoblast | Homo sapiens | 2021-01-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00772 | USP7 | USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-01-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00773 | USP7 | USP7 promotes cell proliferation through the stabilization of Ki-67 protein innon-small cell lung cancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-08-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00774 | USP7 | HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-09-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00775 | USP7 | USP7 Deubiquitinates and Stabilizes SIRT1. | Manual (Western-based) | HeLa | Homo sapiens | 2019-10-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00776 | USP7 | Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated byO-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). | Manual (Western-based) | HEK293T | Homo sapiens | 2015-12-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00777 | USP7 | Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histonedeacetylase SIRT7 regulates gluconeogenesis. | Manual (Western-based) | HCT116 | Homo sapiens | 2017-06-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00778 | USP7 | Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKTdegradation through autophagy flux. | Manual (Western-based) | OPM2 | Homo sapiens | 2020-03-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00779 | USP7 | The herpesvirus associated ubiquitin specific protease, USP7, is a negativeregulator of PML proteins and PML nuclear bodies. | Manual (Western-based) | CNE2 | Homo sapiens | 2011-01-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00780 | USP7 | USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblasticleukemia. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-10-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00781 | USP7 | Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. | Manual (Western-based) | HEK293T | Homo sapiens | 2015-05-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00782 | USP7 | The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3stabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-04-23 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00783 | USP7 | Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. | Manual (Western-based) | MCF-7 | Homo sapiens | 2016-05-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00784 | USP7 | USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymeraseeta stability. | Manual (Western-based) | XP30RO | Homo sapiens | 2014-12-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00785 | USP7 | FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. | Manual (Western-based) | HEK293T | Homo sapiens | 2006-09-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00786 | USP8 | USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. | Manual (Western-based) | HEK293T | Homo sapiens | 2014-09-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00787 | USP8 | The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 tosuppress its autophagic activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-07-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00788 | USP8 | Neuregulin-induced ErbB3 downregulation is mediated by a protein stabilitycascade involving the E3 ubiquitin ligase Nrdp1. | Manual (Western-based) | HEK293T | Homo sapiens | 2007-01-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00789 | USP8 | CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-06-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00790 | USP8 | HIF1alpha deubiquitination by USP8 is essential for ciliogenesis in normoxia. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-12-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00791 | USP8 | USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-04-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00792 | USP8 | Deubiquitylation and stabilization of Notch1 intracellular domain byubiquitin-specific protease 8 enhance tumorigenesis in breast cancer. | Manual (Western-based) | H1299 | Homo sapiens | 2019-09-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00793 | USP8 | UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2006-11-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00794 | USP8 | USP8 modulates ubiquitination of LRIG1 for Met degradation. | Manual (Western-based) | EBC-1 | Homo sapiens | 2014-05-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00795 | USP8 | The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 EnzymeUbiquitination and Degradation. | Manual (Western-based) | H4 neuroglioma | Homo sapiens | 2016-06-14 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00796 | USP8 | Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-07-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00797 | USP8 | Deubiquitinase Usp8 regulates alpha-synuclein clearance and modifies its toxicityin Lewy body disease. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-07-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00798 | USP8 | Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control ofFLIPS stability and TRAIL sensitivity in glioblastoma multiforme. | Manual (Western-based) | GBM xenograft | Homo sapiens | 2010-05-18 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00799 | USP8 | BRUCE regulates DNA double-strand break response by promoting USP8deubiquitination of BRIT1. | Manual (Western-based) | U2-OS | Homo sapiens | 2015-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00800 | USP8 | Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPIIcarriers and collagen IV secretion. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-03-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00801 | USP8 | Effect of deubiquitinase USP8 on hypoxia/reoxygenationinduced inflammation bydeubiquitination of TAK1 in renal tubular epithelial cells. | Manual (Western-based) | HK-2 | Homo sapiens | 2018-09-17 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00802 | USP8 | VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the UbiquitinIsopeptidase USP8. | Manual (Western-based) | HUVEC | Homo sapiens | 2015-12-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00803 | USP8 | Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellularresponsiveness to Wg/Wnt. | Manual (Western-based) | HeLa | Homo sapiens | 2010-05-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00804 | USP8 | The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-04-06 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00805 | USP8 | The deubiquitinating enzyme USP8 promotes trafficking and degradation of thechemokine receptor 4 at the sorting endosome. | Manual (Western-based) | HEK293T | Homo sapiens | 2010-09-27 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00806 | USP8 | Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of theepithelial Na+ channel. | Manual (Western-based) | HEK293T | Homo sapiens | 2013-01-07 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00807 | USP9X | Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. | Manual (Western-based) | HEK293T | Homo sapiens | 2009-12-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00808 | USP9X | Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Controlof ZAP70 Ubiquitination and PKCbeta Kinase Activity. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-03-02 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00809 | USP9X | Deubiquitinase ubiquitin-specific protease 9X regulates the stability andfunction of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00810 | USP9X | Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependentmitotic transcription and survival. | Manual (Western-based) | HEK293T | Homo sapiens | 2020-03-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00811 | USP9X | Deubiquitinase USP9X deubiquitinates beta-catenin and promotes high grade glioma cell growth. | Manual (Western-based) | U251 | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00812 | USP9X | SFI1 promotes centriole duplication by recruiting USP9X to stabilize themicrocephaly protein STIL. | Manual (Western-based) | HeLa | Homo sapiens | 2019-06-13 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00813 | USP9X | Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-05-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00814 | USP9X | Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features oflung cancer via PGE2 signaling. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-06-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00815 | USP9X | USP9X controls translation efficiency via deubiquitination of eukaryotictranslation initiation factor 4A1. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00816 | USP9X | IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth viaErk1/2 activation in prostate carcinoma cell line. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00817 | USP9X | Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscularatrophy protein-survival motor neuron. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-10-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00818 | USP9X | Arginine methylation of USP9X promotes its interaction with TDRD3 and itsanti-apoptotic activities in breast cancer cells. | Manual (Western-based) | HeLa | Homo sapiens | 2017-01-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00819 | USP9X | The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming duringmouse development. | Manual (Western-based) | ES | Homo sapiens | 2021-03-25 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00820 | USP9X | USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance byepigenetically inducing TGF-beta2 transcription. | Manual (Western-based) | SPCA1 | Homo sapiens | 2021-02-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00821 | USP9X | Regulation of T cell function by the ubiquitin-specific protease USP9X viamodulating the Carma1-Bcl10-Malt1 complex. | Manual (Western-based) | JTAg | Homo sapiens | 2013-05-20 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00822 | USP9X | Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cellscooperatively by inhibiting the mutant kinase through aggresomal translocationand inducing oxidative stress. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-04-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00823 | USP9X | USP9X regulates centrosome duplication and promotes breast carcinogenesis. | Manual (Western-based) | MCF-7 | Homo sapiens | 2017-03-31 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00824 | USP9X | USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in humancancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-09-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00825 | USP9X | Deubiquitinase ubiquitin-specific protease 9X regulates the stability andfunction of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-02-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00826 | USP9X | mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR. | Manual (Western-based) | HeLa | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00827 | USP9X | USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance inaggressive B-cell lymphoma. | Manual (Western-based) | HeLa | Homo sapiens | 2016-08-01 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00828 | USP9X | Deubiquitination and stabilization of programmed cell death ligand 1 byubiquitin-specific peptidase 9, X-linked in oral squamous cell carcinoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-07-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00829 | USP9X | Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-09-05 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00830 | USP9X | Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizingpericentriolar material 1 protein. | Manual (Western-based) | HeLa | Homo sapiens | 2019-01-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00831 | USP9X | USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00832 | USP9X | USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 toregulate ciliogenesis. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-05-12 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00833 | USP9X | Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinaseUSP9X limits the occurrence and toxicity of oxidative stress in human cells. | Manual (Western-based) | HeLa | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00834 | USP9X | Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumorsuppressor kinase 2 (LATS2) in the Hippo pathway. | Manual (Western-based) | HeLa | Homo sapiens | 2017-11-28 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00835 | USP9X | Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interactionwith the USP9x deubiquitinase. | Manual (Western-based) | T47D | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00836 | USP9X | The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectalcancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-02-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00837 | USP9X | USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wntsignaling and promotes breast carcinogenesis. | Manual (Western-based) | HeLa | Homo sapiens | 2019-05-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00838 | USP9X | Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression andtumorigenicity in melanoma. | Manual (Western-based) | HEK293T | Homo sapiens | 2017-02-15 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00839 | USP9X | IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth viaErk1/2 activation in prostate carcinoma cell line. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-09-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00840 | USP9X | A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lungcancer. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-03-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00841 | USP9X | Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1)degradation and thereby stimulates prostate cancer cell apoptosis. | Manual (Western-based) | PC3 | Homo sapiens | 2019-02-04 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00842 | USP9X | The ubiquitin E3 ligase MARCH7 is differentially regulated by thedeubiquitylating enzymes USP7 and USP9X. | Manual (Western-based) | HEK293T | Homo sapiens | 2008-04-11 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00843 | USP9X | Identification of a USP9X Substrate NFX1-123 by SILAC-Based QuantitativeProteomics. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-05-22 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00844 | USP9X | Deubiquitinating enzyme USP9X regulates cellular clock function by modulating theubiquitination and degradation of a core circadian protein BMAL1. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-04-30 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00845 | USP9X | Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 proteinand protects it from ligase activity-dependent self-degradation. | Manual (Western-based) | HEK293T | Homo sapiens | 2012-11-26 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00846 | USP9X | Interplay of Endosomal pH and Ligand Occupancy in Integrin alpha5beta1Ubiquitination, Endocytic Sorting, and Cell Migration. | Manual (Western-based) | HeLa | Homo sapiens | 2015-10-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00847 | USP9X | USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance byepigenetically inducing TGF-beta2 transcription. | Manual (Western-based) | H460 | Homo sapiens | 2021-02-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00848 | USP9X | FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controlsSmad4 monoubiquitination. | Manual (Western-based) | HEK293T | Homo sapiens | 2021-11-03 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00849 | USP9X | Upregulation of DR5 and Downregulation of Survivin by IITZ-01, LysosomotropicAutophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cellsvia Ubiquitin-Proteasome Pathway. | Manual (Western-based) | Caki-1 | Homo sapiens | 2020-08-21 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00850 | USP9X | USP9X promotes apoptosis in cholangiocarcinoma by modulation expression ofKIF1Bbeta via deubiquitinating EGLN3. | Manual (Western-based) | RBE | Homo sapiens | 2021-06-10 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00851 | USP9X | Targeting USP9x/SOX2 axis contributes to the anti-osteosarcoma effect ofneogambogic acid. | Manual (Western-based) | HEK293T | Homo sapiens | 2019-10-09 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00852 | USP9X | USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells. | Manual (Western-based) | NHA | Homo sapiens | 2019-04-08 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00853 | USP9X | Deubiquitylating enzyme USP9x regulates hippo pathway activity by controllingangiomotin protein turnover. | Manual (Western-based) | HEK293T | Homo sapiens | 2016-03-29 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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| DXP00854 | USP9X | The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistancethrough YAP1 stabilization. | Manual (Western-based) | HEK293T | Homo sapiens | 2018-02-16 | 2021-11-03 |
Ugo Mayor (UPV/EHU)
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